X0306 4 2022-08-02 0 0001697532 Applied Therapeutics Inc. APLT 0001775404 Kanter Stacy J. C/O APPLIED THERAPEUTICS, INC. 545 FIFTH AVENUE, SUITE 1400 NEW YORK NY 10017 1 0 0 0 Employee Stock Option (Right to Buy) 1.22 2022-08-02 4 D 0 16500 D 2032-06-02 Common Stock 16500 0 D Employee Stock Option (Right to Buy) 1.05 2022-08-02 4 D 0 16500 A 2032-06-02 Common Stock 16500 16500 D Employee Stock Option (Right to Buy) 19.70 2022-08-02 4 D 0 16500 D 2031-06-02 Common Stock 16500 0 D Employee Stock Option (Right to Buy) 1.05 2022-08-02 4 D 0 16500 A 2031-06-02 Common Stock 16500 16500 D Employee Stock Option (Right to Buy) 44.02 2022-08-02 4 D 0 10230 D 2030-06-03 Common Stock 10230 0 D Employee Stock Option (Right to Buy) 1.05 2022-08-02 4 D 0 10230 A 2030-06-03 Common Stock 10230 10230 D Employee Stock Option (Right to Buy) 10.00 2022-08-02 4 D 0 20460 D 2029-05-12 Common Stock 20460 0 D Employee Stock Option (Right to Buy) 1.05 2022-08-02 4 D 0 20460 A 2029-05-12 Common Stock 20460 20460 D The transaction reported herein reflects a one-time stock option repricing that became effective on August 2, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these Options. Reflects an initial grant of 16,500 Options granted on June 3, 2022 that vests as follows: One-twelfth (1/12th) of the shares subject to the Option shall vest on July 2, 2022 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date. These Options are fully vested. /s/ Shoshana Shendelman, as attorney-in-fact 2022-08-04