X0306 4 2022-03-21 0 0001697532 Applied Therapeutics Inc. APLT 0001775410 Perfetti Riccardo C/O APPLIED THERAPEUTICS, INC. 545 5TH AVENUE, SUITE 1400 NEW YORK NY 10017 0 1 0 0 Chief Medical Officer Common Stock 2022-03-21 4 P 0 12548 1.85 A 108948 D Common Stock 2022-03-22 4 P 0 21961 1.98 A 130909 D Common Stock 2022-03-23 4 P 0 30000 1.97 A 160909 D These shares were purchased by Dr. Perfetti in multiple transactions. Weighted average price. These shares were purchased by Dr. Perfetti in multiple transactions at prices ranging from $1.8100 to $1.9200 inclusive. The reporting undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were purchased by Dr. Perfetti in multiple transactions at prices ranging from $1.9000 to $2.0900 inclusive. The reporting undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were purchased by Dr. Perfetti in multiple transactions at prices ranging from $1.8600 to $2.1000 inclusive. The reporting undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. /s/ Shoshana Shendelman as attorney-in-fact 2022-03-23