X0306 4 2022-01-07 0 0001697532 Applied Therapeutics Inc. APLT 0001805556 Hansard Adam C/O APPLIED THERAPEUTICS, INC. 545 5TH AVENUE, SUITE 1400 NEW YORK NY 10017 0 1 0 0 Chief Commercial Officer Common Stock 2022-01-07 4 A 0 31700 0.00 A 96970 D Employee Stock Option (Right to Buy) 4.17 2022-01-07 4 A 0 21100 0.00 A 2032-01-07 Common Stock 21100 21100 D Consists of compensatory Restricted Stock Units granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. Each compensatory Restricted Stock Unit represents a contingent right to receive one share of the issuer's common stock. One-fourth (1/4th) of the compensatory Restricted Stock Units shall vest on January 7, 2023, and one-twelfth (1/12th) of the remaining shares subject to the compensatory Restricted Stock Units shall vest each quarter thereafter, subject to the Reporting Person continuing to provide services through each such date. Consists of compensatory Options granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. One-fourth (1/4th) of the shares subject to the compensatory Option shall vest on January 7, 2023, and one thirty-sixth (1/36th) of the remaining shares subject to the compensatory Option shall vest each month thereafter, subject to the Reporting Person continuing to provide services through each such date. /s/ Shoshana Shendelman as attorney-in-fact 2022-01-11