X0306 4 2021-12-14 0 0001697532 Applied Therapeutics Inc. APLT 0001775410 Perfetti Riccardo C/O APPLIED THERAPEUTICS, INC. 545 5TH AVENUE, SUITE 1400 NEW YORK NY 10017 0 1 0 0 Chief Medical Officer Common Stock 2021-12-14 4 A 0 48200 0.00 A 48200 D Employee Stock Option (Right to Buy) 9.44 2021-12-14 4 A 0 32100 0.00 A 2031-12-14 Common Stock 32100 32100 D Consists of compensatory Restricted Stock Units granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. Each compensatory Restricted Stock Unit represents a contingent right to receive one share of the issuer's common stock. One-fourth (1/4th) of the compensatory Restricted Stock Units shall vest on each of December 14, 2022, December 14, 2023, December 14, 2024 and December 14, 2025, subject to the Reporting Person continuing to provide services through each such date. Consists of compensatory options granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan. One-fourth (1/4th) of the shares subject to the compensatory Option shall vest on December 14, 2022, and one thirty-sixth (1/36th) of the remaining shares subject to the compensatory Option shall vest each month thereafter, subject to the Reporting Person continuing to provide services through each such date. /s/ Shoshana Shendelman as attorney-in-fact 2021-12-16