X0306 4 2021-07-13 0 0001697532 Applied Therapeutics Inc. APLT 0001775410 Perfetti Riccardo C/O APPLIED THERAPEUTICS, INC. 545 5TH AVENUE, SUITE 1400 NEW YORK NY 10017 0 1 0 0 Chief Medical Officer Common Stock 2021-07-13 4 M 0 460 1.44 A 460 D Common Stock 2021-07-13 4 S 0 460 21.25 D 0 D Common Stock 2021-07-14 4 M 0 460 1.44 D 460 D Common Stock 2021-07-14 4 S 0 460 20.51 D 0 D Common Stock 2021-07-15 4 M 0 460 1.44 A 460 D Common Stock 2021-07-15 4 S 0 460 19.54 D 0 D Stock Option (Right to Buy) 1.44 2021-07-13 4 M 0 460 0.00 D 2028-12-16 Common Stock 460 164667 D Stock Option (Right to Buy) 1.44 2021-07-14 4 M 0 460 0.00 D 2028-12-16 Common Stock 460 164207 D Stock Option (Right to Buy) 1.44 2021-07-15 4 M 0 460 0.00 D 2028-12-16 Common Stock 460 163747 D Compensatory options granted under Applied Therapeutics, Inc.'s 2016 Equity Incentive Plan, exercised automatically pursuant to the reporting person's written trading plan previously entered into on September 16, 2020, providing for the sale of shares underlying compensatory options in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. Automatic sales made pursuant to the reporting person's pre-existing written trading plan, providing for the sale of shares underlying compensatory options in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. Weighted average price. These shares were sold in multiple transactions at prices ranging from $20.8200 to $21.4850 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $20.1300 to $20.6850 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $19.3500 to $19.7650 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Thirty-three percent (33%) of the shares subject to the option vested on August 27, 2018, and one twenty-fourth (1/24th) of the remaining shares subject to the Option vested or shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date. /s/ Shoshana Shendelman, Attorney-in-Fact 2021-07-15