X0306 4 2021-06-03 0 0001697532 Applied Therapeutics Inc. APLT 0001775410 Perfetti Riccardo C/O APPLIED THERAPEUTICS, INC. 545 5TH AVENUE, SUITE 1400 NEW YORK NY 10017 0 1 0 0 Chief Medical Officer Common Stock 2021-06-03 4 M 0 460 1.44 A 460 D Common Stock 2021-06-03 4 S 0 460 19.66 D 0 D Common Stock 2021-06-04 4 M 0 460 1.44 A 460 D Common Stock 2021-06-04 4 S 0 460 19.65 D 0 D Common Stock 2021-06-07 4 M 0 460 1.44 A 460 D Common Stock 2021-06-07 4 S 0 200 20.43 D 260 D Common Stock 2021-06-07 4 S 0 260 21.38 D 0 D Stock Option (Right to Buy) 1.44 2021-06-03 4 M 0 460 0.00 D 2028-12-16 Common Stock 460 170514 D Stock Option (Right to Buy) 1.44 2021-06-04 4 M 0 460 0.00 D 2028-12-16 Common Stock 460 170054 D Stock Option (Right to Buy) 1.44 2012-06-07 4 M 0 460 0.00 D 2028-12-16 Common Stock 460 169594 D Compensatory options granted under Applied Therapeutics, Inc.'s 2016 Equity Incentive Plan, exercised automatically pursuant to the reporting person's written trading plan previously entered into on September 16, 2020, providing for the sale of shares underlying compensatory options in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. Automatic sales made pursuant to the reporting person's pre-existing written trading plan, providing for the sale of shares underlying compensatory options in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. Weighted average price. These shares were sold in multiple transactions at prices ranging from $19.4900 to $19.7900 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $19.5400 to $19.9000 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $19.9700 to $20.8300 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $21.2900 to $21.4500 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Thirty-three percent (33%) of the shares subject to the option vested on August 27, 2018, and one twenty-fourth (1/24th) of the remaining shares subject to the Option vested or shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date. /s/ Shoshana Shendelman, Attorney-in-Fact 2021-06-07