X0306 4 2021-05-10 0 0001697532 Applied Therapeutics Inc. APLT 0001808486 Mahadevan Chids C/O APPLIED THERAPEUTICS 545 5TH AVENUE, SUITE 1400 NEW YORK NY 10017 0 1 0 0 Chief Accounting Officer Common Stock 2021-05-10 4 A 0 8544 0.00 A 8544 D Common Stock 25 D Stock Option (Right to Buy) 17.05 2021-05-10 4 A 0 13412 0.00 A 2031-05-10 Common Stock 13412 13412 D Consists of Restricted Stock Units, representing a contingent right to receive one share of the issuer's common stock. One-fourth (1/4th) of the Restricted Stock Units were vested upon grant and one-fourth (1/4th) of the Restricted Stock Unites shall vest thereafter on each of May 10, 2022, May 10, 2023 and May 10, 2024,subject to the Reporting Person continuing to provide services through each such date. One-fourth (1/4th) of the shares subject to the Option were vested upon grant and the remainder of the shares subject to the Option shall vest thereafter in equal monthly installments over the three-year period following the date of grant, subject to the Reporting Person continuing to provide services through each such date. /s/ Shoshana Shendelman, Attorney-in-Fact 2021-05-14