X0306 4 2020-06-02 0 0001697532 Applied Therapeutics Inc. APLT 0001775394 Funtleyder Leslie D. C/O APPLIED THERAPEUTICS, INC. 545 FIFTH AVENUE, SUITE 1400 NEW YORK NY 10017 1 0 0 0 Common Stock 2020-06-02 4 M 0 15000 4.70 A 32148 D Common Stock 2020-06-02 4 S 0 12486 45.21 D 19662 D Common Stock 2020-06-03 4 S 0 1032 44.03 D 18630 D Common Stock 2020-06-04 4 S 0 1482 44.17 D 17148 D Stock Option (Right to Buy) 4.70 2020-06-02 4 M 0 15000 0.00 D 2029-03-06 Common Stock 15000 144502 D Stock Option (Right to Buy) 44.02 2020-06-04 4 A 0 10230 0.00 A 2030-06-03 Common Stock 10230 10230 D Weighted average price. These shares were sold in multiple transactions at prices ranging from $45.0000 to $45.7500 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $44.0100 to $44.1100 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $44.0000 to $44.5400 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. These options became fully vested on May 28, 2019. One-twelfth (1/12th) of the shares subject to the Option shall vest on July 4, 2020 and each month thereafter, subject to the Reporting Person continuing to provide services through each such date. /s/ Shoshana Shendelman as attorney-in-fact 2020-06-04