X0306 4 2020-05-28 0 0001697532 Applied Therapeutics Inc. APLT 0001775394 Funtleyder Leslie D. C/O APPLIED THERAPEUTICS, INC. 545 FIFTH AVENUE, SUITE 1400 NEW YORK NY 10017 1 0 0 0 Common Stock 2020-05-28 4 M 0 18453 0.04 A 35601 D Common Stock 2020-05-28 4 S 0 2838 48.27 D 32763 D Common Stock 2020-05-29 4 S 0 7120 44.27 D 25643 D Common Stock 2020-05-29 4 S 0 8495 45.08 D 17148 D Stock Option (Right to Buy) 0.04 2020-05-28 4 M 0 18453 0.00 D 2028-06-21 Common Stock 18453 0 D Weighted average price. These shares were sold in multiple transactions at prices ranging from $48.0000 to $48.4800 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $43.6200 to $44.6100 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. Weighted average price. These shares were sold in multiple transactions at prices ranging from $44.6800 to $45.5900 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. These options became fully vested on April 22, 2019. /s/ Shoshana Shendelnman as attorney-in-fact 2020-06-01