SCHEDULE 13G/A 0001104659-19-032050 0001035443 XXXXXXXX LIVE 7 Common Stock, par value $0.0001 per share 12/11/2025 0001697532 Applied Therapeutics, Inc. 03828A101 545 Fifth Avenue New York NY 10017 Rule 13d-1(c) Alexandria Real Estate Equities, Inc. b MD 0.00 6500000.00 0.00 6500000.00 6500000.00 4.3 CO Alexandria Venture Investments, LLC b DE 0.00 4450000.00 0.00 4450000.00 4450000.00 3.0 OO Alexandria Equities No. 7, LLC b DE 0.00 2050000.00 0.00 2050000.00 2050000.00 1.4 OO Applied Therapeutics, Inc. 545 Fifth Avenue, New York, NY, 10017. The names of the persons filing this report (collectively, the "Reporting Persons") are: Alexandria Real Estate Equities, Inc. ("ARE") Alexandria Venture Investments, LLC ("AVI") Alexandria Equities No. 7, LLC ("AE7") The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G/A. 26 North Euclid Avenue Pasadena, CA 91101 ARE is incorporated in the State of Maryland AVI is organized in the State of Delaware AE7 is organized in the State of Delaware Y Row 9 of each Reporting Person's cover page to this Schedule 13G/A sets forth the aggregate number of shares of common stock of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. The Reporting Persons' ownership of the Issuer's securities consists of (i) 1,500,000 shares of the Issuer's common stock issuable upon exercise of pre-funded warrants ("Pre-Funded Warrants") held directly by AVI that are currently exercisable; (ii) 2,950,000 shares of the Issuer's common stock issuable upon exercise of common stock warrants (the "Common Stock Warrants" and, collectively with the Pre-Funded Warrants, the "Warrants") held directly by AVI that are currently exercisable; and (iii) 2,050,000 shares of the Issuer's common stock issuable upon exercise of Common Stock Warrants held directly by AE7 that are currently exercisable. Each of AVI and AE7 are indirect, wholly-owned subsidiaries of ARE and, accordingly, ARE may be deemed to share voting and dispositive power with AVI and AE7 with respect to the securities reported herein. Row 11 of each Reporting Person's cover page to this Schedule 13G/A sets forth the percentages of the shares of common stock of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. The percentage set forth in each row 11 is based upon upon 144,300,674 shares of common stock outstanding as of November 12, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on November 13, 2025, and giving effect to Warrants, as referenced herein. Row 5 of each Reporting Person's cover page to this Schedule 13G/A sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 6 of each Reporting Person's cover page to this Schedule 13G/A sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 7 of each Reporting Person's cover page to this Schedule 13G/A sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 8 of each Reporting Person's cover page to this Schedule 13G/A sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. N Y Y N Each of AVI and AE7 is the wholly owned subsidiary of ARE, which has the exclusive power to vote and dispose of shares directly owned by these subsidiaries. N The Reporting Persons are filing this Schedule 13G/A jointly, but not as members of a group, and each expressly disclaims membership in a group. Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit A to the Reporting Persons' Schedule 13G/A filed with the SEC on November 13, 2024). Alexandria Real Estate Equities, Inc. /s/ Marc E. Binda 12/15/2025 Alexandria Venture Investments, LLC /s/ Marc E. Binda 12/15/2025 Alexandria Equities No. 7, LLC /s/ Marc E. Binda 12/15/2025 Note 1: By ARE-Special Services, LLC, managing member, By Alexandria Real Estate Equities, L.P., its managing member, By ARE-QRS Corp., its general partner, By: Alexandria Real Estate Equities, Inc., its sole shareholder, By Marc E. Binda, Chief Financial Officer and Treasurer