X0306 4 2022-06-22 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 false true false false CHIEF FINANCIAL OFFICER Common Stock 2022-06-22 4 M 0 1077 A 82012 D Common Stock 2022-06-23 4 S 0 427 35.76 D 81585 D Restricted Stock Unit 2022-06-22 4 M 0 1077 0 D Common Stock 1077 3232 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of RSUs and in compliance with Rule 10b5-1. The RSUs vest over four years. 25% of the RSUs vested on March 22, 2020 and the remaining shares vest in 12 equal quarterly installments thereafter. /s/ Tami Chen, Attorney-in-Fact 2022-06-24