X0306 4 2020-09-21 0 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 0 1 0 0 Chief Financial Officer Common Stock 2020-09-21 4 M 0 1117 A 57347 D Common Stock 2020-09-22 4 M 0 1077 A 58424 D Common Stock 2020-09-22 4 S 0 447 62.69 D 57977 D Common Stock 2020-09-22 4 M 0 1625 10.41 D 59602 D Common Stock 2020-09-22 4 S 0 40 61.01 D 59562 D Common Stock 2020-09-22 4 S 0 1480 63.2432 D 58082 D Common Stock 2020-09-22 4 S 0 105 63.9533 D 57997 D Common Stock 2020-09-23 4 S 0 670 63.31 D 57307 D Common Stock 2020-09-23 4 S 0 430 63.3108 D 56877 D Restricted Stock Unit 2020-09-21 4 M 0 1117 0 D Common Stock 1117 2235 D Restricted Stock Unit 2020-09-22 4 M 0 1077 0 D Common Stock 1077 10773 D Stock Option (right to buy) 10.41 2020-09-22 4 M 0 1625 0 D 2027-09-08 Common Stock 1625 18884 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting March 21, 2018. Each RSU represents a contingent right to receive one share of the common stock of the issuer. Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting March 22, 2020. The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of RSUs. The Reporting Person is subject to a Lock-Up Letter Agreement. The sale of shares is a permissible exemption under the terms of the Lock-Up Letter Agreement. The sales reported in this Form 4 effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2019. The sale of shares is a permissible exemption under the terms of the Lock-Up Letter Agreement. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.69 to $63.67 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.78 to $64.00 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.31 to $63.4283 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. These reported shares are subject to restrictions in a Lock-Up Letter Agreement that expire on November 10, 2020. The RSUs vest over four years. 25% of the RSUs vest on March 21, 2018 and the remaining shares vest in 12 equal quarterly installments thereafter. The RSUs vest over four years. 25% of the RSUs vest on March 22, 2020 and the remaining shares vest in 12 equal quarterly installments thereafter. The option shares vest over four years. 25% of the option shares vested and became exercisable on March 21, 2018 and the remaining shares vest in 36 equal monthly installments thereafter. The exercise of this option is a permissible exemption under the terms of the Lock-Up Letter Agreement. /s/ Tami Chen, attorney-in-fact 2020-09-23