X0306 4 2020-09-09 0 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 0 1 0 0 Chief Financial Officer Common Stock 2020-09-09 4 M 0 3021 A 57466 D Common Stock 2020-09-10 4 S 0 1236 60.7726 D 56230 D Restricted Stock Unit 2020-09-09 4 M 0 3021 0 D Common Stock 3021 18125 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting March 9, 2019. Each RSU represents a contingent right to receive one share of the common stock of the issuer. The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of RSUs. The Reporting Person is subject to a Lock-Up Letter Agreement. The sale of shares is a permissible exemption under the terms of the Lock-Up Letter Agreement. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.76 to $61.15 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. These reported shares are subject to restrictions in a Lock-Up Letter Agreement that expire on November 10, 2020. The RSUs vest over four years. 25% of the RSUs vest on March 9, 2019 and the remaining shares vest in 12 equal quarterly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-09-11