X0306 4 2020-06-23 0 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 0 1 0 0 Chief Financial Officer Common Stock 2020-06-23 4 M 0 12500 A 54166 D Common Stock 2020-06-24 4 S 0 5049 45.4706 D 49117 D Common Stock 2020-06-24 4 S 0 4572 46.0188 D 44545 D Common Stock 2020-06-24 4 S 0 400 46.64 D 44145 D Restricted Stock Units 2029-06-23 4 M 0 12500 0 D Common Stock 12500 37500 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting September 19, 2019. Each RSU represents a contingent right to receive one share of the common stock of the issuer. The sale of shares was effected in order to satisfy tax liabilities due at the time of vesting. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.47 to $45.4975 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2019. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.47 to $46.44 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. On March 22, 2019, the Reporting Person was granted RSUs covering 100,000 shares of common stock, which vests in tranches upon the Reporting Person achieving certain milestones relating to a combination of the passage of time and the Reporting Person achieving certain milestones relating to the Issuer's stock price, based on the average closing price per share of the Issuer's common stock for a calendar month, calculated as of the last day of such calendar month. On June 23, 2020, the criteria was satisfied for the vesting of RSUs covering 12,500 shares of common stock. /s/ Tami Chen, attorney-in-fact 2020-06-25