X0306 4 2020-05-22 0 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 0 1 0 0 Chief Financial Officer Common Stock 2020-05-22 4 M 0 3251 10.41 A 26525 D Common Stock 2020-05-22 4 S 0 3251 45.4483 D 23274 D Stock Option (right to buy) 10.41 2020-05-22 4 M 0 3251 0 D 2027-06-08 Common Stock 3251 25387 D The sales reported in this Form 4 effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2019. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.19 to $45.76 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option shares vest over four years. 25% of the option shares vested and became exercisable on March 21, 2018 and the remaining shares vest in 36 equal monthly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-05-27