X0306 4 2020-02-03 0 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 0 1 0 0 Chief Financial Officer Common Stock 2020-02-03 4 M 0 625 9.59 A 19126 D Common Stock 2020-02-03 4 M 0 1626 10.41 A 20752 D Common Stock 2020-02-03 4 S 0 2251 35.22 D 18501 D Stock Option (right to buy) 9.59 2020-02-03 4 M 0 625 0 D 2026-04-07 Common Stock 625 1250 D Stock Option (right to buy) 10.41 2020-02-03 4 M 0 1626 0 D 2027-06-08 Common Stock 1626 31890 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 31, 2019. The option shares vest over four years. 25% of the option shares vest and become exercisable on April 1, 2017 and the remaining shares vest in 36 equal monthly installments thereafter. The option shares vest over four years. 25% of the option shares vest and become exercisable on March 21, 2018 and the remaining shares vest in 36 equal monthly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-02-04