The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AC IMMUNE SA SHS H00263105   759,231 153,380 SH   SOLE   153,380 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   1,307,685 348,716 SH   SOLE   348,716 0 0
AGILENT TECHNOLOGIES INC COM 00846U101   3,102,159 19,431 SH   SOLE   19,431 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   11,911,299 70,240 SH   SOLE   70,240 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206   35,632,028 10,573,302 SH   SOLE   10,573,302 0 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105   30,850,340 6,440,572 SH   SOLE   6,440,572 0 0
ANAPTYSBIO INC COM 032724106   6,345,767 182,612 SH   SOLE   182,612 0 0
ANTHEM INC COM 036752103   15,896,641 34,294 SH   SOLE   34,294 0 0
ARGENX SE SPONSORED ADR 04016X101   7,527,684 21,496 SH   SOLE   21,496 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302   40,693,000 664,484 SH   SOLE   664,484 0 0
ARK ETF TR INNOVATION ETF 00214Q104   11,267,372 119,118 SH   SOLE   119,118 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   54,306,801 403,678 SH   SOLE   403,678 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108   722,300 310,000 SH   SOLE   310,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   55,292,298 949,224 SH   SOLE   949,224 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   4,605,652 201,384 SH   SOLE   201,384 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   2,083,993 401,540 SH   SOLE   401,540 0 0
AVANTOR INC COM 05352A100   47,427,095 1,125,465 SH   SOLE   1,125,465 0 0
AVROBIO INC COM 05455M100   1,174,208 304,989 SH   SOLE   304,989 0 0
BIOGEN INC COM 09062X103   7,927,197 33,041 SH   SOLE   33,041 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105   43,427,927 315,129 SH   SOLE   315,129 0 0
BROOKDALE SR LIVING INC COM 112463104   408,393 79,146 SH   SOLE   79,146 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   22,893,350 592,478 SH   SOLE   592,478 0 0
CENTENE CORP DEL COM 15135B101   18,508,111 224,613 SH   SOLE   224,613 0 0
CERNER CORP COM 156782104   7,221,692 77,543 SH   SOLE   77,543 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108   85,044,751 6,389,538 SH   SOLE   6,389,538 0 0
CUREVAC N V COM N2451R105   2,916,933 85,017 SH   SOLE   85,017 0 0
CYCLERION THERAPEUTICS INC COM 23255M105   639,763 371,955 SH   SOLE   371,955 0 0
DANAHER CORPORATION COM 235851102   55,983,620 170,053 SH   SOLE   170,053 0 0
DEXCOM INC COM 252131107   3,437,017 6,401 SH   SOLE   6,401 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   502,775 114,008 SH   SOLE   114,008 0 0
ENSIGN GROUP INC COM 29358P101   873,504 10,397 SH   SOLE   10,397 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104   38,269,368 849,298 SH   SOLE   849,298 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   1,699,010 25,137 SH   SOLE   25,137 0 0
EXELIXIS INC COM 30161Q104   9,792,596 535,700 SH   SOLE   535,700 0 0
F-STAR THERAPEUTICS INC COM 30315R107   250,664 49,933 SH   SOLE   49,933 0 0
FATE THERAPEUTICS INC COM 31189P102   14,907,763 254,790 SH   SOLE   254,790 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105   25,039,082 567,205 SH   SOLE   567,205 0 0
GLYCOMIMETICS INC COM 38000Q102   144,000 100,000 SH   SOLE   100,000 0 0
GOSSAMER BIO INC COM 38341P102   451,382 39,910 SH   SOLE   39,910 0 0
GRITSTONE BIO INC COM 39868T105   2,187,808 170,125 SH   SOLE   170,125 0 0
GUARDANT HEALTH INC COM 40131M109   10,035,407 100,334 SH   SOLE   100,334 0 0
HCA HEALTHCARE INC COM 40412C101   12,613,230 49,094 SH   SOLE   49,094 0 0
HEALTHEQUITY INC COM 42226A107   14,747,492 333,352 SH   SOLE   333,352 0 0
HESKA CORP COM RESTRC NEW 42805E306   825,767 4,525 SH   SOLE   4,525 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   89,844,900 833,750 SH   SOLE   833,750 0 0
HUMANA INC COM 444859102   12,719,675 27,382 SH   SOLE   27,382 0 0
ICON PLC SHS G4705A100   16,063,210 51,867 SH   SOLE   51,867 0 0
INSULET CORP COM 45784P101   8,027,864 30,172 SH   SOLE   30,172 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   12,131,732 231,787 SH   SOLE   231,787 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   3,530,123 9,825 SH   SOLE   9,825 0 0
IONIS PHARMACEUTICALS INC COM 462222100   11,709,129 384,789 SH   SOLE   384,789 0 0
IQVIA HLDGS INC COM 46266C105   6,945,723 24,618 SH   SOLE   24,618 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106   8,611,260 73,169 SH   SOLE   73,169 0 0
KARUNA THERAPEUTICS INC COM 48576A100   2,087,354 15,934 SH   SOLE   15,934 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409   14,303,468 45,522 SH   SOLE   45,522 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   3,142,914 797,694 SH   SOLE   797,694 0 0
LIQUIDIA CORPORATION COM NEW 53635D202   7,051,263 1,447,898 SH   SOLE   1,447,898 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102   672,443 291,101 SH   SOLE   291,101 0 0
MAGELLAN HEALTH INC COM NEW 559079207   9,945,453 104,700 SH   SOLE   104,700 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107   3,678,611 87,795 SH   SOLE   87,795 0 0
MCKESSON CORP COM 58155Q103   33,898,274 136,111 SH   SOLE   136,111 0 0
MERCK & CO INC COM 58933Y105   5,025,107 19,456 SH   SOLE   19,456 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107   415,152 259,470 SH   SOLE   259,470 0 0
MERUS N V COM N5749R100   604,200 19,000 SH   SOLE   19,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   963,931 147,165 SH   SOLE   147,165 0 0
MIRATI THERAPEUTICS INC COM 60468T105   2,176,880 14,840 SH   SOLE   14,840 0 0
MYOMO INC COM NEW 62857J201   1,026,750 150,000 SH   SOLE   150,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109   11,220,300 265,695 SH   SOLE   265,695 0 0
NATERA INC COM 632307104   9,532,411 102,071 SH   SOLE   102,071 0 0
NEVRO CORP COM 64157F103   5,356,619 66,074 SH   SOLE   66,074 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101   553,847 419,581 SH   SOLE   419,581 0 0
ORTHO CLINICAL DIAGNOSTICS H ORD SHS G6829J107   18,954,535 886,140 SH   SOLE   886,140 0 0
PERKINELMER INC COM 714046109   6,206,521 30,869 SH   SOLE   30,869 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107   3,398,410 1,117,898 SH   SOLE   1,117,898 0 0
QIAGEN NV SHS NEW N72482123   9,033,640 162,534 SH   SOLE   162,534 0 0
R1 RCM INC COM 749397105   18,687,535 733,132 SH   SOLE   733,132 0 0
REPLIGEN CORP COM 759916109   1,214,027 4,584 SH   SOLE   4,584 0 0
SANOFI SPONSORED ADR 80105N105   1,937,467 38,672 SH   SOLE   38,672 0 0
SI-BONE INC COM 825704109   5,732,268 258,094 SH   SOLE   258,094 0 0
SONIDA SENIOR LIVING INC COM 140475203   433,304 15,209 SH   SOLE   15,209 0 0
SURGALIGN HOLDINGS INC COM 86882C105   1,374,587 1,918,743 SH   SOLE   1,918,743 0 0
SYNEOS HEALTH INC CL A 87166B102   8,790,640 85,612 SH   SOLE   85,612 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108   9,077,477 181,151 SH   SOLE   181,151 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   18,434,999 2,301,498 SH   SOLE   2,301,498 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   84,686,074 391,920 SH   SOLE   391,920 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   3,847,025 194,589 SH   SOLE   194,589 0 0
VOCERA COMMUNICATIONS INC COM 92857F107   970,655 14,970 SH   SOLE   14,970 0 0
XENON PHARMACEUTICALS INC COM 98420N105   6,545,374 209,519 SH   SOLE   209,519 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107   5,309,482 63,163 SH   SOLE   63,163 0 0
ZOGENIX INC COM NEW 98978L204   8,953,198 550,966 SH   SOLE   550,966 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   1,974,564 84,600 SH Call SOLE   84,600 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302   14,930,312 243,800 SH Call SOLE   243,800 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   33,336,475 572,300 SH Call SOLE   572,300 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108   16,999,532 1,277,200 SH Call SOLE   1,277,200 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105   66,313,170 1,503,700 SH Call SOLE   1,503,700 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   7,543,200 70,000 SH Call SOLE   70,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655   27,806,250 125,000 SH Put SOLE   125,000 0 0
ISHARES TR RUS 2000 GRW ETF 464287648   26,374,500 90,000 SH Put SOLE   90,000 0 0
MERCK & CO INC COM 58933Y105   3,732,368 48,700 SH Call SOLE   48,700 0 0
PROGYNY INC COM 74340E103   2,517,500 50,000 SH Put SOLE   50,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   114,023,810 286,600 SH Put SOLE   286,600 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   20,664,360 94,100 SH Call SOLE   94,100 0 0
SPDR SER TR S&P BIOTECH 78464A870   12,741,048 113,800 SH Call SOLE   113,800 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   7,708,824 962,400 SH Call SOLE   962,400 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   1,642,208 7,600 SH Call SOLE   7,600 0 0