AFFIMED N V COM N01045108 4351894 942989 SH SOLE 942989 0 0 ALBIREO PHARMA INC COM 01345P106 2066988 78029 SH SOLE 78029 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 33119819 4786101 SH SOLE 4786101 0 0 AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 4220154 886587 SH SOLE 886587 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 13747639 420932 SH SOLE 420932 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 32588878 220344 SH SOLE 220344 0 0 ASTRAZENECA PLC SPONSORED ADR 046353108 29732166 562151 SH SOLE 562151 0 0 AURINIA PHARMACEUTICALS INC COM 05156V102 8910281 548325 SH SOLE 548325 0 0 AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 4141511 258360 SH SOLE 258360 0 0 BIOCRYST PHARMACEUTICALS INC COM 09058V103 23099729 4847792 SH SOLE 4847792 0 0 BIODELIVERY SCIENCES INTL IN COM 09060J106 2544077 583504 SH SOLE 583504 0 0 BIOHAVEN PHARMACTL HLDG CO L COM G11196105 32772581 448264 SH SOLE 448264 0 0 BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 810300 30000 SH SOLE 30000 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 9265074 712698 SH SOLE 712698 0 0 CHEMOCENTRYX INC COM 16383L106 2350049 40842 SH SOLE 40842 0 0 COMMUNITY HEALTH SYS INC NEW COM 203668108 1481739 492272 SH SOLE 492272 0 0 CONCERT PHARMACEUTICALS INC COM 206022105 2318181 232983 SH SOLE 232983 0 0 CYCLERION THERAPEUTICS INC COM 23255M105 1463688 247663 SH SOLE 247663 0 0 CYTOKINETICS INC COM NEW 23282W605 3339869 141700 SH SOLE 141700 0 0 DANAHER CORPORATION COM 235851102 19089983 107857 SH SOLE 107857 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 25001897 418652 SH SOLE 418652 0 0 DEXCOM INC COM 252131107 2704018 6670 SH SOLE 6670 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 3274187 128905 SH SOLE 128905 0 0 DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 867486 97800 SH SOLE 97800 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 470477 49008 SH SOLE 49008 0 0 ENSIGN GROUP INC COM 29358P101 17904163 427307 SH SOLE 427307 0 0 FATE THERAPEUTICS INC COM 31189P102 18227462 531258 SH SOLE 531258 0 0 FLUIDIGM CORP DEL COM 34385P108 1876371 467923 SH SOLE 467923 0 0 GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 9270058 227263 SH SOLE 227263 0 0 HCA HEALTHCARE INC COM 40412C101 2950624 30400 SH SOLE 30400 0 0 HESKA CORP COM RESTRC NEW 42805E306 26111452 280256 SH SOLE 280256 0 0 HORIZON THERAPEUTICS PUB LTD SHS G46188101 53064338 954738 SH SOLE 954738 0 0 IMMUNOVANT INC COM 45258J102 298677 12266 SH SOLE 12266 0 0 KALVISTA PHARMACEUTICALS INC COM 483497103 1086653 89806 SH SOLE 89806 0 0 KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 2081716 81700 SH SOLE 81700 0 0 LIQUIDIA TECHNOLOGIES INC COM 53635D202 7238876 859724 SH SOLE 859724 0 0 MODEL N INC COM 607525102 11844957 340764 SH SOLE 340764 0 0 MOMENTA PHARMACEUTICALS INC COM 60877T100 4136725 124338 SH SOLE 124338 0 0 MYOKARDIA INC COM 62857M105 6820792 70594 SH SOLE 70594 0 0 MYOVANT SCIENCES LTD COM G637AM102 15682562 760551 SH SOLE 760551 0 0 OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 531919 79037 SH SOLE 79037 0 0 OTONOMY INC COM 68906L105 2176210 601163 SH SOLE 601163 0 0 OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 4551794 350138 SH SOLE 350138 0 0 PACIRA BIOSCIENCES COM 695127100 6960408 132655 SH SOLE 132655 0 0 PENNANT GROUP INC COM 70805E109 2318037 102568 SH SOLE 102568 0 0 PROTARA THERAPEUTICS INC COM STK 74365U107 1357809 46310 SH SOLE 46310 0 0 PROTHENA CORP PLC SHS G72800108 1592148 152213 SH SOLE 152213 0 0 QIAGEN NV SHS NEW N72482123 3530369 82466 SH SOLE 82466 0 0 RADIUS HEALTH INC COM NEW 750469207 3000099 220110 SH SOLE 220110 0 0 SANOFI SPONSORED ADR 80105N105 2541167 49778 SH SOLE 49778 0 0 SAREPTA THERAPEUTICS INC COM 803607100 11501349 71731 SH SOLE 71731 0 0 SCPHARMACEUTICALS INC COM 810648105 1821004 247419 SH SOLE 247419 0 0 SESEN BIO INC COM 817763105 1440000 2000000 SH SOLE 2000000 0 0 SOLID BIOSCIENCES INC COM 83422E105 1192580 407024 SH SOLE 407024 0 0 TARO PHARMACEUTICAL INDS LTD SHS M8737E108 6992687 105169 SH SOLE 105169 0 0 TELIGENT INC NEW COM NEW 87960W203 859095 354998 SH SOLE 354998 0 0 TG THERAPEUTICS INC COM 88322Q108 48724779 2501272 SH SOLE 2501272 0 0 UNIQURE NV SHS N90064101 1033136 22928 SH SOLE 22928 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 28153796 232676 SH SOLE 232676 0 0 VAPOTHERM INC COM 922107107 2943861 71819 SH SOLE 71819 0 0 XOMA CORP DEL COM NEW 98419J206 1265747 64056 SH SOLE 64056 0 0 ZOGENIX INC COM NEW 98978L204 27201312 1007083 SH SOLE 1007083 0 0 ZYMEWORKS INC COM 98985W102 1442800 40000 SH SOLE 40000 0 0 AIR LEASE CORP CL A 00912X302 585800 20000 SH Put SOLE 20000 0 0 ALIGN TECHNOLOGY INC COM 016255101 2744400 10000 SH Put SOLE 10000 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 7475676 1080300 SH Call SOLE 1080300 0 0 SPDR S&P 500 ETF TR TR UNIT 78462F103 104842400 340000 SH Put SOLE 340000 0 0 SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 8005600 80000 SH Put SOLE 80000 0 0 ZOGENIX INC COM NEW 98978L204 148555 5500 SH Call SOLE 5500 0 0