AFFIMED N V COM N01045108 924631 322171 SH SOLE 322171 0 0 AKORN INC COM 009728106 677946 131640 SH SOLE 131640 0 0 ALBIREO PHARMA INC COM 01345P106 581255 18029 SH SOLE 18029 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 6322878 87140 SH SOLE 87140 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 30210880 1558065 SH SOLE 1558065 0 0 ANTHEM INC COM 036752103 2822100 10000 SH SOLE 10000 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 2972610 117309 SH SOLE 117309 0 0 AQUINOX PHARMACEUTICALS INC COM 03842B101 173972 73717 SH SOLE 73717 0 0 ARENA PHARMACEUTICALS INC COM NEW 040047607 4309364 73501 SH SOLE 73501 0 0 ARGENX SE SPONSORED ADR 04016X101 6833217 48264 SH SOLE 48264 0 0 ARQULE INC COM 04269E107 4973085 451688 SH SOLE 451688 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 15706115 136397 SH SOLE 136397 0 0 AUDENTES THERAPEUTICS INC COM 05070R104 6039654 159526 SH SOLE 159526 0 0 BIOCRYST PHARMACEUTICALS COM 09058V103 1297923 342460 SH SOLE 342460 0 0 BIODELIVERY SCIENCES INTL IN COM 09060J106 1656674 356274 SH SOLE 356274 0 0 CARETRUST REIT INC COM 14174T107 1498529 62464 SH SOLE 62464 0 0 CENTENE CORP DEL COM 15135B101 5223024 99600 SH SOLE 99600 0 0 COLLEGIUM PHARMACEUTICAL INC COM 19459J104 1854150 141000 SH SOLE 141000 0 0 CYCLERION THERAPEUTICS INC COM 23255M105 216691 18925 SH SOLE 18925 0 0 CYMABAY THERAPEUTICS INC COM 23257D103 603559 84296 SH SOLE 84296 0 0 DANAHER CORPORATION COM 235851102 20761378 145104 SH SOLE 145104 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 6883004 305233 SH SOLE 305233 0 0 DERMIRA INC COM 24983L104 3822795 399874 SH SOLE 399874 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 646916 41074 SH SOLE 41074 0 0 EHEALTH INC COM 28238P109 15389428 178739 SH SOLE 178739 0 0 EIGER BIOPHARMACEUTICALS INC COM 28249U105 738905 69708 SH SOLE 69708 0 0 ENSIGN GROUP INC COM 29358P101 17401664 305483 SH SOLE 305483 0 0 FATE THERAPEUTICS INC COM 31189P102 4422477 217856 SH SOLE 217856 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 626868 263390 SH SOLE 263390 0 0 GENOMIC HEALTH INC COM 37244C101 2233903 38403 SH SOLE 38403 0 0 GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 28091890 693685 SH SOLE 693685 0 0 HESKA CORP COM RESTRC NEW 42805E306 2974477 34924 SH SOLE 34924 0 0 HUMANA INC COM 444859102 2658140 10000 SH SOLE 10000 0 0 ILLUMINA INC COM 452327109 6733464 18290 SH SOLE 18290 0 0 INVACARE CORP COM 461203101 1091369 210283 SH SOLE 210283 0 0 LTC PPTYS INC COM 502175102 1508013 33027 SH SOLE 33027 0 0 MACROGENICS INC COM 556099109 3234872 190623 SH SOLE 190623 0 0 MEDICINES CO COM 584688105 2086084 57200 SH SOLE 57200 0 0 MYOKARDIA INC COM 62857M105 2840531 56652 SH SOLE 56652 0 0 NUVASIVE INC COM 670704105 5373855 91798 SH SOLE 91798 0 0 OMEGA HEALTHCARE INVS INC COM 681936100 1521450 41400 SH SOLE 41400 0 0 OPTINOSE INC COM 68404V100 744150 105106 SH SOLE 105106 0 0 OTONOMY INC COM 68906L105 534680 194429 SH SOLE 194429 0 0 PFENEX INC COM 717071104 545724 80968 SH SOLE 80968 0 0 PROVENTION BIO INC COM 74374N102 891298 73661 SH SOLE 73661 0 0 PTC THERAPEUTICS INC COM 69366J200 2187000 48600 SH SOLE 48600 0 0 R1 RCM INC COM 749397105 33955420 2699159 SH SOLE 2699159 0 0 RADIUS HEALTH INC COM NEW 750469207 17308194 710517 SH SOLE 710517 0 0 SABRA HEALTH CARE REIT INC COM 78573L106 1547634 78600 SH SOLE 78600 0 0 SANOFI SPONSORED ADR 80105N105 11512503 266062 SH SOLE 266062 0 0 SAREPTA THERAPEUTICS INC COM 803607100 2515380 16554 SH SOLE 16554 0 0 SAVARA INC COM 805111101 573879 242143 SH SOLE 242143 0 0 SCPHARMACEUTICALS INC COM 810648105 556007 174297 SH SOLE 174297 0 0 TELIGENT INC NEW COM 87960W104 1628735 2584883 SH SOLE 2584883 0 0 TG THERAPEUTICS INC COM 88322Q108 7642284 883501 SH SOLE 883501 0 0 TRICIDA INC COM 89610F101 3455433 87568 SH SOLE 87568 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 10608350 57849 SH SOLE 57849 0 0 XENON PHARMACEUTICALS INC COM 98420N105 2211992 224340 SH SOLE 224340 0 0 ZOGENIX INC COM NEW 98978L204 25648017 536794 SH SOLE 536794 0 0 BIOCRYST PHARMACEUTICALS COM 09058V103 385822 101800 SH Call SOLE 101800 0 0 ZOGENIX INC COM NEW 98978L204 1739192 36400 SH Put SOLE 36400 0 0 ZOGENIX INC COM NEW 98978L204 4983454 104300 SH Call SOLE 104300 0 0