The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 110,457 88,363 SH   SOLE   88,363 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 8,853 7,082 SH   SOLE 1 7,082 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 BBG00VR8SF73 8,340 748 SH   SOLE 1 748 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 BBG00VR8SF73 106,072 9,513 SH   SOLE   9,513 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 7,923 1,105 SH   SOLE 1 1,105 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 98,322 13,713 SH   SOLE   13,713 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 52,172 19,041 SH   SOLE   19,041 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 4,316 1,575 SH   SOLE 1 1,575 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 6,841,774 219,993 SH   SOLE   219,993 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 187,719 6,036 SH   SOLE 1 6,036 0 0
COGENT BIOSCIENCES INC COM 19240Q201 BBG007DHY102 120,074 17,868 SH   SOLE   17,868 0 0
COGENT BIOSCIENCES INC COM 19240Q201 BBG007DHY102 9,455 1,407 SH   SOLE 1 1,407 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 42,137 19,329 SH   SOLE   19,329 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 3,401 1,560 SH   SOLE 1 1,560 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 1,416,076 34,597 SH   SOLE 1 34,597 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 4,907,582 119,903 SH   SOLE   119,903 0 0
DEERE & CO COM 244199105 BBG001S5QFF7 454,027 1,105 SH   SOLE 1 1,105 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 6,268,192 212,267 SH   SOLE   212,267 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 391,014 13,241 SH   SOLE 1 13,241 0 0
FLEXSHARES TR STOX GBL ESG SLT 33939L688 BBG00D9WQ9Z5 9,349,943 57,404 SH   SOLE   57,404 0 0
GERON CORP COM 374163103 BBG001S6TSX4 4,340 1,315 SH   SOLE 1 1,315 0 0
GERON CORP COM 374163103 BBG001S6TSX4 54,653 16,561 SH   SOLE   16,561 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 23,130 406 SH   SOLE 1 406 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 291,970 5,125 SH   SOLE   5,125 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 5,604,610 264,996 SH   SOLE   264,996 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 191,326 9,046 SH   SOLE 1 9,046 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 113,402 6,919 SH   SOLE 1 6,919 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 506,669 30,913 SH   SOLE   30,913 0 0
INVESCO EXCHANGE TRADED FD T DORSEY WRIGHT MO 46137V837 BBG001SJ09N0 1,917,214 19,409 SH   SOLE   19,409 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 1,666,601 64,966 SH   SOLE   64,966 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 3,866 151 SH   SOLE 1 151 0 0
ISHARES TR 0-5 YR TIPS ETF 46429B747 BBG001TG5H89 2,234,275 22,471 SH   SOLE   22,471 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 83,171 879 SH   SOLE 1 879 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 422,382 4,464 SH   SOLE   4,464 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 898,052 7,753 SH   SOLE   7,753 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 165,514 1,429 SH   SOLE 1 1,429 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 167,157 1,766 SH   SOLE 1 1,766 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 1,006,616 10,633 SH   SOLE   10,633 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 4,767,438 43,255 SH   SOLE   43,255 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 379,431 3,443 SH   SOLE 1 3,443 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 2,679,723 5,098 SH   SOLE   5,098 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 41,657 79 SH   SOLE 1 79 0 0
ISHARES TR ESG AW MSCI EAFE 46435G516 BBG00D7BBRS7 16,601,193 207,750 SH   SOLE   207,750 0 0
ISHARES TR FLTG RATE NT ETF 46429B655 BBG001V1QYX1 1,091,381 21,374 SH   SOLE   21,374 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 323,758 6,799 SH   SOLE 1 6,799 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 4,709,728 98,904 SH   SOLE   98,904 0 0
ISHARES TR GLOBAL REIT ETF 46434V647 BBG006S5D3J3 361,223 15,254 SH   SOLE   15,254 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 22,472 207 SH   SOLE 1 207 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 3,589,043 32,951 SH   SOLE   32,951 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 12,889 144 SH   SOLE 1 144 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 6,021,331 67,150 SH   SOLE   67,150 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 5,223,220 56,515 SH   SOLE   56,515 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 166,298 1,799 SH   SOLE 1 1,799 0 0
ISHARES TR MSCI INDIA ETF 46429B598 BBG002DMN4B6 716,740 13,893 SH   SOLE   13,893 0 0
ISHARES TR MSCI USA MIN VOL 46429B697 BBG0025X2G81 1,012,047 12,110 SH   SOLE   12,110 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 310,005 1,654 SH   SOLE 1 1,654 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 6,248,497 33,350 SH   SOLE   33,350 0 0
ISHARES TR SHORT TREAS BD 464288679 BBG001SSD803 1,561,562 14,127 SH   SOLE   14,127 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 1,795,667 16,718 SH   SOLE   16,718 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 271,983 2,532 SH   SOLE 1 2,532 0 0
JPMORGAN CHASE & CO COM 46625H100 BBG001S8CRC3 2,604 13 SH   SOLE   13 0 0
JPMORGAN CHASE & CO COM 46625H100 BBG001S8CRC3 647,411 3,232 SH   SOLE 1 3,232 0 0
KRONOS BIO INC COM 50107A104 BBG00L072932 7,670 5,900 SH   SOLE 1 5,900 0 0
KRONOS BIO INC COM 50107A104 BBG00L072932 92,601 71,231 SH   SOLE   71,231 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 18,861 216 SH   SOLE 1 216 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 238,483 2,736 SH   SOLE   2,736 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 10,570 3,203 SH   SOLE 1 3,203 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 134,028 40,614 SH   SOLE   40,614 0 0
NUSHARES ETF TR NUVEEN ESG LRGVL 67092P300 BBG00FJ5HBJ1 15,516,150 399,284 SH   SOLE   399,284 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 1,566,246 1,733 SH   SOLE 1 1,733 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 2,712 3 SH   SOLE   3 0 0
PFIZER INC COM 717081103 BBG001S5V466 329,082 11,857 SH   SOLE   11,857 0 0
PFIZER INC COM 717081103 BBG001S5V466 27,830 1,003 SH   SOLE 1 1,003 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 10,738,308 193,274 SH   SOLE   193,274 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 396,293 7,133 SH   SOLE 1 7,133 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 6,259 1,962 SH   SOLE 1 1,962 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 79,170 24,818 SH   SOLE   24,818 0 0
PROSHARES TR PSHS ULTRUSS2000 74347R842 BBG001S5RN32 594,679 14,565 SH   SOLE   14,565 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 307,032 319 SH   SOLE   319 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 24,062 25 SH   SOLE 1 25 0 0
SCHWAB STRATEGIC TR US SML CAP ETF 808524607 BBG001T5XQW5 513,299 10,424 SH   SOLE   10,424 0 0
SELECT SECTOR SPDR TR RL EST SEL SEC 81369Y860 BBG00B597137 953,149 24,112 SH   SOLE   24,112 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 BBG001S72SM3 11,415,081 21,823 SH   SOLE   21,823 0 0
SPDR SER TR BLOOMBERG HIGH Y 78468R622 BBG001SQS7X7 2,335,052 24,528 SH   SOLE   24,528 0 0
SPDR SER TR BLOOMBERG INVT 78468R200 BBG0029J2J00 2,123,898 68,891 SH   SOLE   68,891 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 28,218 706 SH   SOLE 1 706 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 5,752,248 143,878 SH   SOLE   143,878 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 BBG001S5WS08 21,602 37 SH   SOLE 1 37 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 BBG001S5WS08 273,351 469 SH   SOLE   469 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 360,111 18,690 SH   SOLE   18,690 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 7,248 376 SH   SOLE 1 376 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 BBG001SL72C5 86,082 11,165 SH   SOLE   11,165 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 BBG001SL72C5 7,055 915 SH   SOLE 1 915 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 378,608 762 SH   SOLE   762 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 30,791 62 SH   SOLE 1 62 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 14,784 301 SH   SOLE 1 301 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 9,998,872 203,269 SH   SOLE   203,269 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 2,446,059 28,287 SH   SOLE   28,287 0 0
VANGUARD INDEX FDS SMALL CP ETF 922908751 BBG001SHTTV0 1,010,343 4,420 SH   SOLE   4,420 0 0
VANGUARD INDEX FDS VALUE ETF 922908744 BBG001SHVR78 1,588,110 9,751 SH   SOLE   9,751 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 1,281,149 30,672 SH   SOLE 1 30,672 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 11,131,969 266,507 SH   SOLE   266,507 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 2,265,519 53,761 SH   SOLE   53,761 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 38,432 912 SH   SOLE 1 912 0 0
VANGUARD TAX-MANAGED FDS VAN FTSE DEV MKT 921943858 BBG001SSPWL4 9,603,352 191,416 SH   SOLE   191,416 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 250,218 3,919 SH   SOLE   3,919 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 147,557 2,311 SH   SOLE 1 2,311 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 5,882 77 SH   SOLE 1 77 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 6,347,880 82,871 SH   SOLE   82,871 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 1,130,035 22,546 SH   SOLE   22,546 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 209,687 4,184 SH   SOLE 1 4,184 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101 BBG011FJXVZ5 6,713 2,612 SH   SOLE 1 2,612 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101 BBG011FJXVZ5 80,765 31,426 SH   SOLE   31,426 0 0