The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 5,334 6,000 SH   SOLE 1 6,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 62,471 70,269 SH   SOLE   70,269 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 131,049 28,865 SH   SOLE   28,865 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 10,964 2,415 SH   SOLE 1 2,415 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 5,361 2,206 SH   SOLE 1 2,206 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 66,968 27,559 SH   SOLE   27,559 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 183,434 6,036 SH   SOLE 1 6,036 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 6,689,711 220,129 SH   SOLE   220,129 0 0
COGENT BIOSCIENCES INC COM 19240Q201 BBG007DHY102 108,703 18,487 SH   SOLE   18,487 0 0
COGENT BIOSCIENCES INC COM 19240Q201 BBG007DHY102 8,791 1,495 SH   SOLE 1 1,495 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 3,565 2,300 SH   SOLE 1 2,300 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 44,249 28,546 SH   SOLE   28,546 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 4,849,128 131,130 SH   SOLE   131,130 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 1,279,416 34,597 SH   SOLE 1 34,597 0 0
DEERE & CO COM 244199105 BBG001S5QFF7 440,320 1,101 SH   SOLE 1 1,101 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 366,651 13,241 SH   SOLE 1 13,241 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 5,994,492 216,487 SH   SOLE   216,487 0 0
FLEXSHARES TR STOX GBL ESG SLT 33939L688 BBG00D9WQ9Z5 9,204,706 61,559 SH   SOLE   61,559 0 0
FLEXSHARES TR STOX US ESG SLCT 33939L696 BBG00DB0LJF7 4,638,144 39,972 SH   SOLE   39,972 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 BBG00V9VQ4K4 149,101 15,515 SH   SOLE   15,515 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 BBG00V9VQ4K4 11,532 1,200 SH   SOLE 1 1,200 0 0
GERON CORP COM 374163103 BBG001S6TSX4 55,107 26,116 SH   SOLE   26,116 0 0
GERON CORP COM 374163103 BBG001S6TSX4 4,642 2,200 SH   SOLE 1 2,200 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 271,127 4,318 SH   SOLE   4,318 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 21,977 350 SH   SOLE 1 350 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 5,635,349 266,071 SH   SOLE   266,071 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 191,597 9,046 SH   SOLE 1 9,046 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 115,098 6,919 SH   SOLE 1 6,919 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 617,361 37,112 SH   SOLE   37,112 0 0
INVESCO EXCHANGE TRADED FD T DORSEY WRIGHT MO 46137V837 BBG001SJ09N0 1,658,808 19,404 SH   SOLE   19,404 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 1,582,386 64,376 SH   SOLE   64,376 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 3,705 151 SH   SOLE 1 151 0 0
ISHARES TR 0-5 YR TIPS ETF 46429B747 BBG001TG5H89 2,117,500 21,478 SH   SOLE   21,478 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 86,916 879 SH   SOLE 1 879 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 515,619 5,215 SH   SOLE   5,215 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 914,266 7,805 SH   SOLE   7,805 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 175,835 1,501 SH   SOLE 1 1,501 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 1,035,018 10,738 SH   SOLE   10,738 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 170,211 1,766 SH   SOLE 1 1,766 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 351,131 3,443 SH   SOLE 1 3,443 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 4,478,711 43,912 SH   SOLE   43,912 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 2,607,521 5,462 SH   SOLE   5,462 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 37,846 79 SH   SOLE 1 79 0 0
ISHARES TR ESG AW MSCI EAFE 46435G516 BBG00D7BBRS7 27,707,794 366,798 SH   SOLE   366,798 0 0
ISHARES TR FLTG RATE NT ETF 46429B655 BBG001V1QYX1 1,071,390 21,165 SH   SOLE   21,165 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 319,882 6,799 SH   SOLE 1 6,799 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 4,720,875 100,340 SH   SOLE   100,340 0 0
ISHARES TR GLOBAL REIT ETF 46434V647 BBG006S5D3J3 366,788 15,169 SH   SOLE   15,169 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 3,625,676 32,766 SH   SOLE   32,766 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 22,831 207 SH   SOLE 1 207 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 5,983,437 67,184 SH   SOLE   67,184 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 12,802 144 SH   SOLE 1 144 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 5,323,206 56,580 SH   SOLE   56,580 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 169,286 1,799 SH   SOLE 1 1,799 0 0
ISHARES TR MSCI INDIA ETF 46429B598 BBG002DMN4B6 678,117 13,893 SH   SOLE   13,893 0 0
ISHARES TR MSCI USA MIN VOL 46429B697 BBG0025X2G81 947,324 12,143 SH   SOLE   12,143 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 259,603 1,654 SH   SOLE 1 1,654 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 5,533,586 35,268 SH   SOLE   35,268 0 0
ISHARES TR SHORT TREAS BD 464288679 BBG001SSD803 1,350,126 12,259 SH   SOLE   12,259 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 289,491 2,693 SH   SOLE 1 2,693 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 1,797,970 16,727 SH   SOLE   16,727 0 0
JPMORGAN CHASE & CO COM 46625H100 BBG001S8CRC3 592,960 3,486 SH   SOLE 1 3,486 0 0
KRONOS BIO INC COM 50107A104 BBG00L072932 4,625 3,700 SH   SOLE 1 3,700 0 0
KRONOS BIO INC COM 50107A104 BBG00L072932 56,839 45,468 SH   SOLE   45,468 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 185,888 2,256 SH   SOLE   2,256 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 14,863 180 SH   SOLE 1 180 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 6,237 2,700 SH   SOLE 1 2,700 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 77,212 33,424 SH   SOLE   33,424 0 0
NKARTA INC COM 65487U108 BBG00JXHS9H6 9,900 1,500 SH   SOLE 1 1,500 0 0
NKARTA INC COM 65487U108 BBG00JXHS9H6 127,162 19,267 SH   SOLE   19,267 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 1,982 4 SH   SOLE   4 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 858,423 1,733 SH   SOLE 1 1,733 0 0
PFIZER INC COM 717081103 BBG001S5V466 275,002 9,553 SH   SOLE   9,553 0 0
PFIZER INC COM 717081103 BBG001S5V466 22,351 776 SH   SOLE 1 776 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 10,974,259 193,618 SH   SOLE   193,618 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 426,046 7,517 SH   SOLE 1 7,517 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 6,552 1,950 SH   SOLE 1 1,950 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 79,024 23,519 SH   SOLE   23,519 0 0
PROSHARES TR PSHS ULTRUSS2000 74347R842 BBG001S5RN32 553,366 14,543 SH   SOLE   14,543 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 259,093 295 SH   SOLE   295 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 21,079 24 SH   SOLE 1 24 0 0
SCHWAB STRATEGIC TR US SML CAP ETF 808524607 BBG001T5XQW5 491,354 10,401 SH   SOLE   10,401 0 0
SELECT SECTOR SPDR TR RL EST SEL SEC 81369Y860 BBG00B597137 1,124,067 28,059 SH   SOLE   28,059 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 BBG001S72SM3 10,331,978 21,737 SH   SOLE   21,737 0 0
SPDR SER TR BLOOMBERG HIGH Y 78468R622 BBG001SQS7X7 2,325,053 24,544 SH   SOLE   24,544 0 0
SPDR SER TR BLOOMBERG INVT 78468R200 BBG0029J2J00 1,899,410 62,092 SH   SOLE   62,092 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 29,601 706 SH   SOLE 1 706 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 6,003,108 143,132 SH   SOLE   143,132 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 BBG001S5WS08 17,594 33 SH   SOLE 1 33 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 BBG001S5WS08 214,996 404 SH   SOLE   404 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 7,197 376 SH   SOLE 1 376 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 367,614 19,217 SH   SOLE   19,217 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 21,061 40 SH   SOLE 1 40 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 264,505 499 SH   SOLE   499 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 14,837 301 SH   SOLE 1 301 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 10,000,594 202,583 SH   SOLE   202,583 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 2,480,233 28,068 SH   SOLE   28,068 0 0
VANGUARD INDEX FDS SMALL CP ETF 922908751 BBG001SHTTV0 940,073 4,407 SH   SOLE   4,407 0 0
VANGUARD INDEX FDS VALUE ETF 922908744 BBG001SHVR78 1,472,890 9,851 SH   SOLE   9,851 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 1,260,600 30,672 SH   SOLE 1 30,672 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 11,270,178 274,214 SH   SOLE   274,214 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 2,339,022 54,919 SH   SOLE   54,919 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 38,841 912 SH   SOLE 1 912 0 0
VANGUARD TAX-MANAGED FDS VAN FTSE DEV MKT 921943858 BBG001SSPWL4 9,115,955 190,312 SH   SOLE   190,312 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 147,326 2,311 SH   SOLE 1 2,311 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 247,499 3,882 SH   SOLE   3,882 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 6,731,246 83,072 SH   SOLE   83,072 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 6,223 77 SH   SOLE 1 77 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 1,448,218 29,068 SH   SOLE   29,068 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 208,432 4,184 SH   SOLE 1 4,184 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101 BBG011FJXVZ5 91,436 19,579 SH   SOLE   19,579 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101 BBG011FJXVZ5 7,706 1,650 SH   SOLE 1 1,650 0 0