The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 BBG001S5N9M6 54,903 497 SH   SOLE   497 0 0
ABBOTT LABS COM 002824100 BBG001S5N9M6 233,751 2,129 SH   SOLE 1 2,129 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 21,960 24,400 SH   SOLE 1 24,400 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 5,513 6,125 SH   SOLE   6,125 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 64,233 12,424 SH   SOLE 1 12,424 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 15,675 3,032 SH   SOLE   3,032 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 13,870 4,375 SH   SOLE   4,375 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 56,981 17,975 SH   SOLE 1 17,975 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 1,178,723 34,967 SH   SOLE   34,967 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 426,600 12,655 SH   SOLE 1 12,655 0 0
CODIAK BIOSCIENCES INC COM 192010106 BBG00BGQ1NR9 31,987 80,455 SH   SOLE 1 80,455 0 0
CODIAK BIOSCIENCES INC COM 192010106 BBG00BGQ1NR9 7,746 19,480 SH   SOLE   19,480 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 31,510 19,694 SH   SOLE 1 19,694 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 8,150 5,093 SH   SOLE   5,093 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 1,606,151 49,839 SH   SOLE   49,839 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 5,685,146 176,394 SH   SOLE 1 176,394 0 0
DEERE & CO COM 244199105 BBG001S5QFF7 466,151 1,087 SH   SOLE 1 1,087 0 0
DESKTOP METAL INC COM CL A 25058X105 BBG00P17H1G9 28,979 21,308 SH   SOLE 1 21,308 0 0
DYADIC INTL INC DEL COM 26745T101 BBG001SJV0D6 14,005 11,385 SH   SOLE   11,385 0 0
DYADIC INTL INC DEL COM 26745T101 BBG001SJV0D6 56,223 45,709 SH   SOLE 1 45,709 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 BBG0026ZCTH6 11,676 9,894 SH   SOLE 1 9,894 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 BBG0026ZCTH6 2,933 2,485 SH   SOLE   2,485 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 3,640,208 136,389 SH   SOLE 1 136,389 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 3,216,197 120,501 SH   SOLE   120,501 0 0
GERON CORP COM 374163103 BBG001S6TSX4 14,126 5,837 SH   SOLE   5,837 0 0
GERON CORP COM 374163103 BBG001S6TSX4 50,965 21,060 SH   SOLE 1 21,060 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 53,092 661 SH   SOLE   661 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 212,847 2,650 SH   SOLE 1 2,650 0 0
INVESCO DB COMMDY INDX TRCK UNIT 46138B103 BBG001SNZTS4 328,911 13,343 SH   SOLE 1 13,343 0 0
INVESCO DB MULTI-SECTOR COMM AGRICULTURE FD 46140H106 BBG001SSDLZ6 808,229 40,111 SH   SOLE 1 40,111 0 0
INVESCO EXCH TRADED FD TR II S&P GBL WATER 46138E263 BBG00KJR22S8 38,976 836 SH   SOLE   836 0 0
INVESCO EXCH TRADED FD TR II S&P GBL WATER 46138E263 BBG00KJR22S8 377,436 8,096 SH   SOLE 1 8,096 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 403,484 19,654 SH   SOLE 1 19,654 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 2,191,250 106,733 SH   SOLE   106,733 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 782,990 49,041 SH   SOLE 1 49,041 0 0
INVESCO EXCHANGE TRADED FD T DWA MOMENTUM 46137V837 BBG001SJ09N0 2,582,791 36,352 SH   SOLE 1 36,352 0 0
ISHARES GOLD TR ISHARES NEW 464285204 BBG001SJK6D5 1,616,840 46,743 SH   SOLE 1 46,743 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 872,074 38,015 SH   SOLE 1 38,015 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 1,621,928 70,704 SH   SOLE   70,704 0 0
ISHARES INC ESG AWR MSCI EM 46434G863 BBG00D7BDH70 224,473 7,465 SH   SOLE 1 7,465 0 0
ISHARES INC ESG AWR MSCI EM 46434G863 BBG00D7BDH70 23,892 794 SH   SOLE   794 0 0
ISHARES TR 0-5 YR TIPS ETF 46429B747 BBG001TG5H89 275,842 2,845 SH   SOLE 1 2,845 0 0
ISHARES TR 0-5 YR TIPS ETF 46429B747 BBG001TG5H89 1,466,907 15,129 SH   SOLE   15,129 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 710,654 7,138 SH   SOLE 1 7,138 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 4,451 44 SH   SOLE   44 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 731,824 6,368 SH   SOLE   6,368 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 1,491,515 12,982 SH   SOLE 1 12,982 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 1,565,399 16,341 SH   SOLE 1 16,341 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 942,032 9,833 SH   SOLE   9,833 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 2,524,478 24,222 SH   SOLE 1 24,222 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 5,395,245 51,755 SH   SOLE   51,755 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 3,589,968 9,345 SH   SOLE   9,345 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 888,267 2,310 SH   SOLE 1 2,310 0 0
ISHARES TR FLTG RATE NT ETF 46429B655 BBG001V1QYX1 1,006,660 20,001 SH   SOLE   20,001 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 4,941,981 107,810 SH   SOLE   107,810 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 3,338,901 72,836 SH   SOLE 1 72,836 0 0
ISHARES TR GLOBAL REIT ETF 46434V647 BBG006S5D3J3 282,308 12,431 SH   SOLE 1 12,431 0 0
ISHARES TR IBOXX HI YD ETF 464288513 BBG001ST0ZQ7 35,155 476 SH   SOLE   476 0 0
ISHARES TR IBOXX HI YD ETF 464288513 BBG001ST0ZQ7 228,530 3,103 SH   SOLE 1 3,103 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 363,414 3,445 SH   SOLE 1 3,445 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 2,625,386 24,899 SH   SOLE   24,899 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 2,755,627 32,574 SH   SOLE   32,574 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 338,273 3,998 SH   SOLE 1 3,998 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 1,611,633 17,376 SH   SOLE   17,376 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 266,160 2,870 SH   SOLE 1 2,870 0 0
ISHARES TR MSCI EMG MKT ETF 464287234 BBG001SK77D5 293,649 7,748 SH   SOLE 1 7,748 0 0
ISHARES TR MSCI USA MIN VOL 46429B697 BBG0025X2G81 783,832 10,872 SH   SOLE   10,872 0 0
ISHARES TR MSCI USA MIN VOL 46429B697 BBG0025X2G81 100,725 1,398 SH   SOLE 1 1,398 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 5,033,750 34,495 SH   SOLE 1 34,495 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 10,492,377 71,899 SH   SOLE   71,899 0 0
ISHARES TR SHORT TREAS BD 464288679 BBG001SSD803 100,027 910 SH   SOLE   910 0 0
ISHARES TR SHORT TREAS BD 464288679 BBG001SSD803 552,624 5,028 SH   SOLE 1 5,028 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 658,421 6,186 SH   SOLE   6,186 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 1,399,556 13,148 SH   SOLE 1 13,148 0 0
JASPER THERAPEUTICS INC COM 471871103 BBG00QPZNPB4 10,986 22,750 SH   SOLE   22,750 0 0
JASPER THERAPEUTICS INC COM 471871103 BBG00QPZNPB4 44,065 91,250 SH   SOLE 1 91,250 0 0
JPMORGAN CHASE & CO COM 46625H100 BBG001S8CRC3 454,578 3,390 SH   SOLE 1 3,390 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 56,524 729 SH   SOLE   729 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 222,302 2,860 SH   SOLE 1 2,860 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 43,425 57,900 SH   SOLE 1 57,900 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 11,701 15,600 SH   SOLE   15,600 0 0
NEW YORK MTG TR INC COM PAR $.02 649604501 BBG001SHHBR7 25,600 10,000 SH   SOLE 1 10,000 0 0
NUSHARES ETF TR NUVEEN ESG LRGVL 67092P300 BBG00FJ5HBJ1 280,076 8,180 SH   SOLE 1 8,180 0 0
NUSHARES ETF TR NUVEEN ESG LRGVL 67092P300 BBG00FJ5HBJ1 22,045,428 643,848 SH   SOLE   643,848 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 356,939 2,442 SH   SOLE 1 2,442 0 0
ORCHARD THERAPEUTICS PLC SPON ADS 68570P101 BBG00M62QW74 48,764 131,439 SH   SOLE 1 131,439 0 0
ORCHARD THERAPEUTICS PLC SPON ADS 68570P101 BBG00M62QW74 12,411 33,455 SH   SOLE   33,455 0 0
PFIZER INC COM 717081103 BBG001S5V466 247,304 4,826 SH   SOLE 1 4,826 0 0
PFIZER INC COM 717081103 BBG001S5V466 80,033 1,561 SH   SOLE   1,561 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 6,997,246 120,141 SH   SOLE   120,141 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 3,946,951 67,770 SH   SOLE 1 67,770 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 15,187 2,865 SH   SOLE   2,865 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 65,747 12,405 SH   SOLE 1 12,405 0 0
PROSHARES TR PSHS ULTRUSS2000 74347R842 BBG001S5RN32 525,200 16,865 SH   SOLE   16,865 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 46,173 64 SH   SOLE   64 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 175,321 243 SH   SOLE 1 243 0 0
SCHWAB STRATEGIC TR US SML CAP ETF 808524607 BBG001T5XQW5 389,383 9,612 SH   SOLE 1 9,612 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 BBG001S7T1S7 535,216 6,119 SH   SOLE 1 6,119 0 0
SELECT SECTOR SPDR TR RL EST SEL SEC 81369Y860 BBG00B597137 1,079,888 29,241 SH   SOLE 1 29,241 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 BBG001S72SM3 7,495,517 19,599 SH   SOLE   19,599 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 BBG001S72SM3 530 1 SH   SOLE 1 1 0 0
SPDR SER TR BLOOMBERG HIGH Y 78468R622 BBG001SQS7X7 282,071 3,134 SH   SOLE   3,134 0 0
SPDR SER TR BLOOMBERG HIGH Y 78468R622 BBG001SQS7X7 90,242 1,003 SH   SOLE 1 1,003 0 0
SPDR SER TR BLOOMBERG INVT 78468R200 BBG0029J2J00 603,414 19,856 SH   SOLE   19,856 0 0
SPDR SER TR BLOOMBERG INVT 78468R200 BBG0029J2J00 554,616 18,250 SH   SOLE 1 18,250 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 1,600,173 38,839 SH   SOLE 1 38,839 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 4,165,818 101,114 SH   SOLE   101,114 0 0
SURFACE ONCOLOGY INC COM 86877M209 BBG00KFWYX53 41,262 50,318 SH   SOLE 1 50,318 0 0
SURFACE ONCOLOGY INC COM 86877M209 BBG00KFWYX53 10,691 13,038 SH   SOLE   13,038 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 165,829 8,900 SH   SOLE 1 8,900 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 488,697 26,232 SH   SOLE   26,232 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 210,808 396 SH   SOLE 1 396 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 68,524 128 SH   SOLE   128 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 580,770 12,245 SH   SOLE 1 12,245 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 1,172,761 24,726 SH   SOLE   24,726 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 4,456,602 54,035 SH   SOLE   54,035 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 353,808 4,288 SH   SOLE 1 4,288 0 0
VANGUARD INDEX FDS SMALL CP ETF 922908751 BBG001SHTTV0 2,068,659 11,271 SH   SOLE   11,271 0 0
VANGUARD INDEX FDS VALUE ETF 922908744 BBG001SHVR78 1,694,659 12,072 SH   SOLE   12,072 0 0
VANGUARD INDEX FDS VALUE ETF 922908744 BBG001SHVR78 292,784 2,083 SH   SOLE 1 2,083 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 10,598,265 271,890 SH   SOLE   271,890 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 4,539,238 116,450 SH   SOLE 1 116,450 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 3,005,468 72,700 SH   SOLE   72,700 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 992,219 24,001 SH   SOLE 1 24,001 0 0
VANGUARD TAX-MANAGED FDS VAN FTSE DEV MKT 921943858 BBG001SSPWL4 11,167,424 266,082 SH   SOLE   266,082 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 351,644 5,767 SH   SOLE 1 5,767 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 4,274,209 51,604 SH   SOLE   51,604 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 869,576 10,500 SH   SOLE 1 10,500 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 1,508,420 35,417 SH   SOLE 1 35,417 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 369,399 8,673 SH   SOLE   8,673 0 0