X0206 3 2018-05-08 0 0001694665 Evelo Biosciences, Inc. EVLO 0001216078 MELAS KYRIAZI THEO 620 MEMORIAL DRIVE, SUITE 200 CAMBRIDGE MA 02139 1 0 0 0 Stock Option 2.49 2027-04-11 Common Stock 56386 D The option vested as to 25% of the total grant on January 24, 2018 and has vested or will vest in equal quarterly installments over a three year period thereafter. Exhibit 24 - Power of Attorney. /s/ Jonathan Poole, Attorney-in-Fact for Theodose Melas-Kyriazi 2018-05-08