The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method.

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Intangible Assets and Goodwill - Additional Information (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020	Dec. 31, 2020
Finite Lived Intangible Assets [Line Items]
Goodwill, Impairment Charges			$ 0	$ 0
Goodwill	$ 21,359,000		21,359,000		$ 21,359,000
Goodwill changes			0
Shire's MRT Program [Member]
Finite Lived Intangible Assets [Line Items]
Goodwill	21,400,000		21,400,000
Shire's MRT Program [Member] \| Sanofi Agreement [Member]
Finite Lived Intangible Assets [Line Items]
Estimated amortization expense of intangible assets for 2021	11,800,000		11,800,000
Estimated amortization expense of intangible assets for 2022	11,200,000		11,200,000
Estimated amortization expense of intangible assets for 2023	11,100,000		11,100,000
Estimated amortization expense of intangible assets for 2024	2,700,000		2,700,000
OTC Deficiency Program [Member]
Finite Lived Intangible Assets [Line Items]
Amortization of Intangible Assets	$ 2,600,000	$ 3,600,000	$ 4,600,000	$ 4,300,000