144 0001693134 XXXXXXXX LIVE 0001933414 Mineralys Therapeutics, Inc. 001-41614 150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087 (888) 378-6240 Levy Adam Scott Officer Common Stock Merrill Lynch

225 Liberty St Floor 37 New York NY 10281

59925 884370.10 65175287 07/30/2025 NASDAQ Common Stock 03/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 35684 03/10/2023 Granted as part of issuer equity compensation plan Common Stock 04/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 3592 04/10/2023 Granted as part of issuer equity compensation plan Common Stock 05/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 3593 05/10/2023 Granted as part of issuer equity compensation plan Common Stock 06/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 3592 06/10/2023 Granted as part of issuer equity compensation plan Common Stock 07/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 3593 07/10/2023 Granted as part of issuer equity compensation plan Common Stock 08/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 3592 08/10/2023 Granted as part of issuer equity compensation plan Common Stock 09/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 3593 09/10/2023 Granted as part of issuer equity compensation plan Common Stock 10/10/2023 Vesting of restricted stock unit award Mineralys Therapeutics, Inc. N 2686 10/10/2023 Granted as part of issuer equity compensation plan N Adam Levy

150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087

Common Stock 07/11/2025 10758 155454.18 Adam Levy

150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087

Common Stock 07/28/2025 12946 181803.62 Adam Levy

150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087

Common Stock 07/29/2025 807 11301.90 07/30/2025 Adam Levy