X0306 4 2020-02-12 0 0001590750 MIRAGEN THERAPEUTICS, INC. MGEN 0001693127 Marshall William Stuart C/O MIRAGEN THERAPEUTICS, INC. 6200 LOOKOUT ROAD BOULDER CO 80301 1 1 0 0 President & CEO Stock Option (right to buy) 0.795 2020-02-12 4 A 0 464000 0.00 A 2030-02-11 Common Stock 464000 464000 D Grant to the Reporting Person of a stock option under the Issuer's 2016 Equity Incentive Plan (the "Plan"). The shares shall vest as follows: (i) 50% shall vest in 48 equal monthly installments beginning on March 12, 2020, (ii) 25% shall vest on completion of a specified milestone related to cobomarsen development and (iii) 25% shall vest on completion of a specified milestone related to MRG-229 development, provided that at the relevant vesting dates the Reporting Person's continuous service to the Issuer has not been terminated as defined in and as determined under the Plan. The shares underlying the option are subject to accelerated vesting upon the occurrence of specified events including a change of control of the Issuer and the Reporting Person's termination. The option expires ten years after the date of grant. /s/ Brent D. Fassett, as Attorney-in-Fact for William S. Marshall 2020-02-14