CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	6 Months Ended
Jun. 30, 2022	Jun. 30, 2021
Operating activities
Net loss	$ (32,145)	$ (23,590)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	357	325
Stock-based compensation expense	3,937	3,390
Amortization of premiums and discounts on marketable securities	(583)	116
Reduction in the carrying value of right-of-use assets	209	183
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	1,273	(216)
Accounts payable	(1,090)	(2,281)
Accrued expenses	(21)	(1,142)
Operating lease liabilities	(358)	(293)
Other assets	25	0
Prepaid expenses - noncurrent	(401)	1,099
Net cash used in operating activities	(28,847)	(22,409)
Investing activities
Purchases of marketable securities	(81,647)	(62,035)
Maturities of marketable securities	81,500	82,560
Purchases of property and equipment	(217)	(278)
Net cash provided by investing activities	(364)	20,247
Financing activities
Net proceeds from issuance of common stock	56,179	0
Net proceeds from issuance of pre-funded warrants	12,150	0
Proceeds from exercise of stock options	244	361
Net cash provided by financing activities	68,573	361
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect, Total	39,362	(1,801)
Effect of foreign currency exchange rate in cash	(58)
Cash, cash equivalents and restricted cash at beginning of period	23,670	28,394
Cash, cash equivalents and restricted cash at end of period	62,974	26,593
Supplemental cash flow information:
Cash and cash equivalents	62,620	26,239
Restricted cash	354	354
Cash, cash equivalents and restricted cash at end of period	62,974	26,593
Property and equipment unpaid at end of period	35	10
Right-of-use asset at adoption of Topic 842	0	2,431
Operating lease liabilities at adoption of Topic 842	0	3,997
Public offering costs included in accounts payable and accrued expenses at balance sheet dates	$ 44	$ 0

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