X0306 4 2019-02-06 0 0001590750 MIRAGEN THERAPEUTICS, INC. MGEN 0001692747 Leverone Jason A. C/O MIRAGEN THERAPEUTICS, INC. 6200 LOOKOUT ROAD BOULDER CO 80301 0 1 0 0 CFO, Treasurer & Secretary Stock Option (right to buy) 2.96 2019-02-06 4 A 0 75000 0.00 A 2029-02-05 Common Stock 75000 75000 D Grant to the Reporting Person of a stock option under the Issuer's 2016 Equity Incentive Plan (the "Plan"). 6.25% of the shares will vest on May 7, 2019 and the remaining 93.75% of the shares will vest in equal monthly installments thereafter over 45 months, such that the stock option shall be fully vested on the four-year anniversary of the date of grant, provided that at the relevant vesting dates the Reporting Person's continuous service to the Issuer has not been terminated as defined in and as determined under the Plan. The shares underlying the option are subject to accelerated vesting upon the occurrence of specified events including a change of control of the Issuer and the Reporting Person's termination. The option expires ten years after the date of grant. /s/ Nathan Jeffries, as Attorney-in-Fact for Jason A. Leverone 2019-02-08