144 0001691494 XXXXXXXX LIVE 0001710072 EDGEWISE THERAPEUTICS, INC. 001-40236 1715 38th Street Boulder CO 80301 7202627002 MARC J SEMIGRAN Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

50000 1499000.00 94688517 12/24/2024 NASDAQ Common 12/24/2024 Exercise of Stock Options Issuer N 50000 12/24/2024 Cash Y The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. Sales that were executed on December 24, 2024 are being reported on this Form 144 filed on December 26, 2024 given the EDGAR system was not accepting filings on December 24, 2024, which is being treated as a federal holiday for filing purposes. 12/24/2024 09/24/2024 /s/ Marc J Semigran