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Stock-based Compensation - Stock Options Activity (Details)
$ / shares in Units, $ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2022
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Number of Options    
Outstanding (in shares) 6,573,744  
Granted (in shares) 4,351,371  
Exercised (in shares) (404,133)  
Cancelled (in shares) (584,411)  
Outstanding (in shares) 9,936,571 6,573,744
Exercisable (in shares) 2,969,722  
Unvested (in shares) 6,966,849  
Weighted- Average Exercise Price    
Outstanding (usd per share) | $ / shares $ 46.03  
Granted (usd per share) | $ / shares 27.47  
Exercised (usd per share) | $ / shares 8.16  
Cancelled (usd per share) | $ / shares 50.66  
Outstanding (usd per share) | $ / shares 39.39 $ 46.03
Exercisable, weighted-average exercise price (usd per share) | $ / shares 27.51  
Unvested, weighted-average exercise price (usd per share) | $ / shares $ 44.45  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]    
Outstanding, weighted-average remaining contractual, term 8 years 5 months 8 days 8 years 3 months 14 days
Exercisable, weighted-average remaining contractual, term 6 years 10 months 17 days  
Unvested, weighted-average remaining contractual, term 9 years 1 month 6 days  
Outstanding, aggregate intrinsic value, outstanding | $ $ 17,050 $ 85,860
Exercisable, aggregate intrinsic value | $ 15,470  
Unvested, aggregate intrinsic value | $ $ 1,580  
Assumed from acquisition (in shares) 72,410