X0306 4 2021-02-05 0 0001817229 Vor Biopharma Inc. VOR 0001690959 Resnick Joshua C/O VOR BIOPHARMA INC. 100 CAMBRIDGEPARK DRIVE, SUITE 400 CAMBRIDGE MA 02140 1 0 0 0 Stock Option (right to buy) 18.00 2021-02-05 4 A 0 16900 0.00 A 2031-02-04 Common Stock 16900 16900 D 1/36th of the shares underlying the option vest in equal monthly installments commencing on March 5, 2021, provided that the Reporting Person remains continuously engaged by the Issuer on each such vesting date. Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund") and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received from the option, which will offset advisory fees owed by the Fund, the Nexus Fund and the Account to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and underlying common stock. /s/ Jason Minio, Attorney-in-Fact 2021-02-09