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Stock-Based Compensation Expense - Effect of Recording Stock-Based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 7,219 $ 8,524 $ 14,627 $ 15,585
Tax effect on stock-based compensation expense (1,159) (2,359) (2,415) (4,379)
Net effect on net income (loss) 6,060 6,165 12,212 11,206
Research, development and other related costs        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense 3,344 3,437 6,438 6,134
Selling, general and administrative        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 3,875 $ 5,087 $ 8,189 $ 9,451