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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities:    
Net loss $ (29,170) $ (22,950)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 506 1,905
Depreciation and amortization expense 421 511
Loss on disposal of property and equipment 3,355 0
Impairment of assets held for sale 270 0
Noncash lease expense 786 699
Loss on lease termination 8,059 0
Net amortization (accretion) of premiums (discounts) on marketable securities (336) 115
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 647 132
Accounts payable (1,159) 1,398
Accrued expenses and other current liabilities (3,339) (859)
Operating lease liabilities (15,639) (692)
Net cash used in operating activities (35,599) (19,741)
Cash flows from investing activities:    
Purchases of property and equipment (245) (27)
Proceeds from sale of property and equipment 1,508 0
Purchases of marketable securities (9,767) (40,117)
Maturities of marketable securities 35,000 0
Net cash provided by (used in) investing activities 26,496 (40,144)
Cash flows from financing activities:    
Net cash provided by financing activities 0 0
Net decrease in cash, cash equivalents and restricted cash (9,103) (59,885)
Cash, cash equivalents and restricted cash at beginning of period 59,406 133,430
Cash, cash equivalents and restricted cash at end of period 50,303 73,545
Supplemental disclosure of non-cash activities:    
Decrease in right-of-use asset and operating lease liabilities due to lease termination $ 14,323 $ 0