Collaboration, License and Other Agreements - Other Agreements (Details) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
License and other agreements
Payment for license agreement					$ 20,000	$ 0
Issuance of common shares as payment for assets		$ 253,779		$ 10,243
Other Agreements
License and other agreements
Milestone payments	$ 0		$ 500		0	650
Other payments	761		3,527		5,206	4,956
Potential developmental milestone payments, maximum	224,812				224,812
Potential regulatory milestone payments, maximum	299,325				299,325
Potential commercial milestone payments, maximum	723,121				723,121
Other Agreements | License agreement
License and other agreements
Payment for license agreement	0		0		3,000	3,700
Issuance of common shares as payment for assets	$ 0		$ 0		$ 1,779	$ 4,243