Collaboration, License and Other Agreements - RPI Agreements (Details) - USD ($)	1 Months Ended	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Aug. 31, 2020
License and other agreements
Interest expense on liability related to sale of future royalties		$ 18,045,000	$ 14,499,000	$ 35,359,000	$ 28,007,000
2018 RPI Funding Agreement
License and other agreements
Proceeds from royalty agreement	$ 100,000,000
Interest expense on liability related to sale of future royalties		14,686,000	12,049,000	28,782,000	23,468,000
Payments under funding agreement		2,595,000	920,000	6,620,000	1,656,000
2020 RPI Funding Agreement
License and other agreements
Interest expense on liability related to sale of future royalties		3,359,000	2,450,000	6,577,000	4,539,000
Payments under funding agreement		$ 494,000	$ 175,000	$ 1,261,000	$ 315,000
Sales-based participation rights sold, value						$ 250,000,000
Revenue Participation Right, tranche one | 2018 RPI Funding Agreement
License and other agreements
Participation rate for revenue participation right (percent)	2.10%
Revenue Participation Right, tranche one | 2018 RPI Funding Agreement | Maximum
License and other agreements
Annual global net sales threshold for revenue participation right	$ 1,500,000,000
Revenue Participation Right, tranche two | 2018 RPI Funding Agreement
License and other agreements
Participation rate for revenue participation right (percent)	1.50%