Share-Based Compensation - Stock Options (Details) $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($) $ / shares shares
Number of shares
Outstanding at beginning of period (in shares)	7,089,727
Granted (in shares)	1,364,434
Exercised (in shares)	(76,161)
Forfeited (in shares)	(19,375)
Outstanding at end of period (in shares)	8,358,625
Options exercisable (in shares)	5,872,531
Options vested and expected to vest (in shares)	8,358,625
Weighted Average Exercise Price
Outstanding at beginning of period (in dollars per share) | $ / shares	$ 40.15
Granted (in dollars per share) | $ / shares	126.36
Exercised (in dollars per share) | $ / shares	57.92
Forfeited (in dollars per share) | $ / shares	80.24
Outstanding at end of period (in dollars per share) | $ / shares	53.96
Options exercisable (in dollars per share) | $ / shares	39.75
Options vested and expected to vest (in dollars per share) | $ / shares	$ 53.93
Weighted Average Contractual Term and Aggregate Intrinsic Value
Weighted average remaining contractual term of options outstanding (in years)	6 years 9 months 18 days
Weighted average remaining contractual term of options exercisable (in years)	6 years 1 month 13 days
Weighted average remaining contractual term of options vested and expected to vest (in years)	6 years 9 months 18 days
Aggregate intrinsic value of options outstanding | $	$ 766,875
Aggregate intrinsic value of options exercisable | $	622,280
Aggregate intrinsic value of options vested and expected to vest | $	$ 766,875
Additional Disclosures
Unvested options expected to vest (in shares)	2,486,094
Stock options
Additional Disclosures
Share-based award term (in years)	10 years
Total unrecognized compensation cost | $	$ 95,791
Weighted average period for recognition of compensation cost	2 years 25 days
Stock options | Minimum
Additional Disclosures
Share-based award vesting period (in years)	3 years
Stock options | Maximum
Additional Disclosures
Share-based award vesting period (in years)	4 years