Liability Related to Sale of Future Royalties, net - Activity within Liability Account (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Liability related to sales of future royalties
Interest expense on liability related to sale of future royalties	$ 18,045	$ 14,499	$ 35,359	$ 28,007
2018 and 2020 RPI Funding Agreements
Liability related to sales of future royalties
Liability related to sale of future royalties - beginning balance			384,283	335,282
Royalty revenues paid and payable to RPI			(7,924)	(3,419)
Interest expense on liability related to sale of future royalties			35,359	28,007
Liability related to sale of future royalties - ending balance	$ 411,718	$ 359,870	$ 411,718	$ 359,870