CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (558,782)	$ (476,487)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash share-based compensation expense	122,094	74,312
Interest expense on mandatorily redeemable preferred shares	0	15,985
Interest expense on liability related to sale of future royalties	35,359	28,007
Deferred interest paid-in-kind on long-term debt	13,037	5,649
Acquisition of IPR&D asset	93,747	0
Issuance of common shares as payment for license agreement	1,779	4,243
Change in fair value of derivatives	107,593	1,700
Gain from equity method investment	0	(5,261)
Depreciation and amortization	9,783	11,278
Change in obligation to perform R&D services	(12,326)	(10,205)
Other non-cash items	373	2,993
Changes in operating assets and liabilities:
Trade receivable, net	(44,180)	(48,526)
Inventory	(29,088)	(19,046)
Prepaid expenses, other current assets, and other assets	(35,273)	(58,173)
Accounts payable	12,466	5,085
Accrued expenses, other current liabilities, and other liabilities	125,738	35,730
Net cash used in operating activities	(157,680)	(432,716)
Cash flows from investing activities:
Purchases of marketable securities	(246,816)	0
Sales of marketable securities	54,015	113,441
Maturities of marketable securities	62,893	48,852
Purchases of property and equipment	(2,393)	(1,657)
Payment for intangible asset	(20,000)	0
Payment for IPR&D asset acquisition	(35,000)	0
Net cash (used in) provided by investing activities	(187,301)	160,636
Cash flows from financing activities:
Proceeds from issuance of long-term debt	125,000	0
Proceeds from issuance of common shares	252,000	308,743
Proceeds from obligation to perform R&D services	0	100,000
Proceeds from the issuance of series B preferred shares	29,158	35,170
Proceeds from exercise of share options	9,983	8,643
Payments for term loan, finance leases, and other	(6,224)	(6,369)
Net cash provided by financing activities	409,917	446,187
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(2,722)	(189)
Net increase in cash, cash equivalents and restricted cash	62,214	173,918
Cash, cash equivalents and restricted cash at beginning of period	174,343	134,231
Cash, cash equivalents and restricted cash at end of period	$ 236,557	$ 308,149