Balance Sheet Components - Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accrued Expense and Other Current Liabilities
Accrued development milestones	$ 25,000	$ 5,000
Accrued employee compensation and benefits	35,917	40,109
Accrued clinical trial costs	34,822	37,477
Accrued commercialization and other professional fees	31,793	19,994
Accrued sales discounts and allowances	292,292	203,760
Current obligation to perform R&D services	30,303	22,030
Other accrued expenses and other current liabilities	95,180	91,649
Accrued expenses and other current liabilities	$ 545,307	$ 420,019