Balance Sheet Components - Prepaid Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Prepaid Expenses
Prepaid clinical trial costs	$ 59,996	$ 42,578
Prepaid manufacturing	1,152	17,448
Prepaid commercial costs	26,940	15,732
Other prepaid expenses	12,272	13,080
Prepaid expenses	$ 100,360	$ 88,838