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Liability Related to Sale of Future Royalties (Tables)
 6 Months Ended
Jun. 30, 2022
Debt Disclosure [Abstract]  
Schedule of reduction to research and development expense The following table shows the activity within the obligation to perform R&D services account for the
three and six months ended June 30, 2022 and 2021, related to the 2020 RPI Funding Agreement.
Three Months Ended June 30,Six Months Ended June 30,
2022202120222021
Reduction to research and development expenses$5,383 $10,016 $12,326 $10,205 
Schedule of liability for sale of future royalties
The following table shows the activity within the liability related to sales of future royalties account for the six months ended June 30, 2022 and 2021, related to the 2018 and 2020 RPI Funding Agreements.
Six Months Ended June 30,
20222021
Liability related to sale of future royalties - beginning balance
$384,283 $335,282 
Royalty revenues paid and payable to RPI(7,924)(3,419)
Interest expense on liability related to sale of future royalties35,359 28,007 
Liability related to sale of future royalties - ending balance
$411,718 $359,870