Collaboration, License and Other Agreements - Other Agreements (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
License and other agreements
Issuance of common shares as payment for assets	$ 253,779	$ 10,243
Other Agreements
License and other agreements
Milestone payments	0	962
Other payments	4,445	1,579
Potential developmental milestone payments, maximum	216,966
Potential regulatory milestone payments, maximum	279,325
Potential commercial milestone payments, maximum	573,121
Other Agreements | License agreement
License and other agreements
Payment for license agreement	$ 3,000	$ 3,700
Issuance of common shares as payment for assets (in shares)	15,340	49,504
Issuance of common shares as payment for assets	$ 1,779	$ 4,243