Share-Based Compensation - Stock Options (Details) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2022 USD ($) $ / shares shares
Number of shares
Outstanding at beginning of period (in shares)	7,089,727
Granted (in shares)	1,243,000
Exercised (in shares)	(46,665)
Forfeited (in shares)	(3,750)
Outstanding at end of period (in shares)	8,282,312
Options exercisable (in shares)	5,689,393
Options vested and expected to vest (in shares)	8,282,312
Weighted Average Exercise Price
Outstanding at beginning of period (in dollars per share) | $ / shares	$ 40.15
Granted (in dollars per share) | $ / shares	128.09
Exercised (in dollars per share) | $ / shares	60.06
Forfeited (in dollars per share) | $ / shares	63.01
Outstanding at end of period (in dollars per share) | $ / shares	53.22
Options exercisable (in dollars per share) | $ / shares	38.82
Options vested and expected to vest (in dollars per share) | $ / shares	$ 53.22
Weighted Average Contractual Term and Aggregate Intrinsic Value
Weighted average remaining contractual term of options outstanding (in years)	7 years 3 days
Weighted average remaining contractual term of options exercisable (in years)	6 years 3 months 21 days
Weighted average remaining contractual term of options vested and expected to vest (in years)	7 years 3 days
Aggregate intrinsic value of options outstanding | $	$ 553,426
Aggregate intrinsic value of options exercisable | $	456,699
Aggregate intrinsic value of options vested and expected to vest | $	$ 553,426
Additional Disclosures
Unvested options expected to vest (in shares)	2,592,919
Stock options
Additional Disclosures
Share-based award term (in years)	10 years
Total unrecognized compensation cost | $	$ 105,422
Weighted average period for recognition of compensation cost	2 years 2 months 23 days
Stock options | Minimum
Additional Disclosures
Share-based award vesting period (in years)	3 years
Stock options | Maximum
Additional Disclosures
Share-based award vesting period (in years)	4 years