CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (116,897)	$ (265,328)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash share-based compensation expense	81,828	48,726
Interest expense on mandatorily redeemable preferred shares	7,917	7,943
Interest expense on liability related to sale of future royalties	17,314	13,508
Deferred interest paid-in-kind on long-term debt	6,450	2,795
Issuance of common shares as payment for license agreement	1,779	4,243
Change in fair value of derivatives	(3,604)	210
Gain from equity method investment	0	(5,261)
Depreciation and amortization	4,402	5,054
Change in obligation to perform R&D services	(6,942)	0
Other non-cash items	(646)	461
Changes in operating assets and liabilities:
Trade receivable, net	(20,073)	(36,658)
Inventory	(23,397)	(17,566)
Prepaid expenses, other current assets, and other assets	(24,954)	(25,619)
Accounts payable	4,518	13,903
Accrued expenses, other current liabilities, and other liabilities	48,661	47,915
Net cash used in operating activities	(23,644)	(205,674)
Cash flows from investing activities:
Purchases of marketable securities	(246,816)	0
Sales of marketable securities	0	113,441
Maturities of marketable securities	3,058	7,515
Purchases of property and equipment	(512)	(1,187)
Net cash (used in) provided by investing activities	(244,270)	119,769
Cash flows from financing activities:
Proceeds from issuance of common shares	252,000	308,743
Proceeds from obligation to perform R&D services	0	100,000
Proceeds from the issuance of series B preferred shares	14,579	17,585
Proceeds from exercise of share options	2,803	1,382
Payments for term loan, finance leases, and other	(1,391)	(6,695)
Net cash provided by financing activities	267,991	421,015
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(46)	14
Net increase in cash, cash equivalents and restricted cash	31	335,124
Cash, cash equivalents and restricted cash at beginning of period	174,343	134,231
Cash, cash equivalents and restricted cash at end of period	$ 174,374	$ 469,355