Balance Sheet Components - Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Accrued Expense and Other Current Liabilities
Accrued development milestones	$ 5,000	$ 5,000
Accrued employee compensation and benefits	35,362	40,109
Accrued clinical trial costs	36,051	37,477
Accrued commercialization and other professional fees	22,744	19,994
Accrued sales discounts and allowances	233,096	203,760
Current obligation to perform R&D services	29,642	22,030
Other accrued expenses and other current liabilities	95,517	91,649
Accrued expenses and other current liabilities	$ 457,412	$ 420,019