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Liability Related to Sale of Future Royalties (Tables)
 3 Months Ended
Mar. 31, 2022
Debt Disclosure [Abstract]  
Schedule of reduction to research and development expense
The following table shows the activity within the obligation to perform R&D services account for the three months ended March 31, 2022 and 2021, related to the 2020 RPI Funding Agreement.
Three Months Ended March 31,
20222021
Reduction to research and development expenses$6,943 190
Schedule of liability for sale of future royalties The following table shows the activity within the liability related to sales of future royalties account for
the three months ended March 31, 2022 and 2021, related to the 2018 and 2020 RPI Funding Agreements.
Three Months Ended March 31,
20222021
Liability related to sale of future royalties - beginning balance
$384,283 $335,282 
Royalty revenues paid and payable to RPI(3,090)(1,096)
Interest expense on liability related to sale of future royalties17,314 13,508 
Liability related to sale of future royalties - ending balance
$398,507 $347,694