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License and Other Agreements - Sosei Heptares (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Nov. 30, 2020
Mar. 31, 2021
Mar. 31, 2020
License and other agreements      
Payment for license agreement   $ 0 $ 20,750
Issuance of common shares as payment for assets   10,243  
Research and development expense   107,111 $ 56,070
Sosei Heptares | Collaborative arrangement      
License and other agreements      
Eligible milestone payment per agreement upon specified performance and regulatory milestones $ 370,000    
Initial term of agreement (in years) 10 years    
Notice period to terminate agreement during research term 180 days    
Notice period to terminate agreement following research term 90 days    
Counterparty notice period after research term to terminate agreement 30 days    
Counterparty continuous period for development activities 365 days    
Research and development expense   $ 617  
Sosei Heptares | Collaborative arrangement | Minimum      
License and other agreements      
Earned royalty payment per agreement (percent) 0.00%    
Sosei Heptares | Collaborative arrangement | Maximum      
License and other agreements      
Earned royalty payment per agreement (percent) 10.00%    
Sosei Heptares | Collaborative arrangement | License agreement      
License and other agreements      
Payment for license agreement $ 5,000    
Issuance of common shares as payment for assets (in shares) 54,617    
Issuance of common shares as payment for assets $ 4,858