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License and Other Agreements - Fox Chase Chemical Diversity Center Agreement (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Nov. 30, 2020
May 31, 2019
Mar. 31, 2021
Mar. 31, 2020
License and other agreements        
Issuance of common shares, net of offering costs     $ 308,243 $ 282,833
Research and development expense     107,111 56,070
FCCDC Agreement | Collaborative arrangement        
License and other agreements        
Common stock issued (shares)   100,000    
Issuance of common shares, net of offering costs   $ 5,646    
Development milestone payment to be paid   4,500    
Development milestone payments to be paid per each additional NDA filing   $ 1,000    
Performance milestone payment to be paid $ 3,800      
Time period for payment of performance milestone 30 months      
Research and development expense     $ 410 $ 955
FCCDC Agreement | Collaborative arrangement | Minimum        
License and other agreements        
Earned royalty payment per agreement (percent) 0.00%      
FCCDC Agreement | Collaborative arrangement | Maximum        
License and other agreements        
Earned royalty payment per agreement (percent) 10.00%      
FCCDC Warrants        
License and other agreements        
Number of securities called by warrants (shares)   100,000    
Exercise price of warrants (in dollars per share)   $ 56.46