CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019
Cash flows from operating activities:
Net loss	$ (550,499)	$ (379,541)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash share-based compensation expense	43,206	34,855
Non-cash interest expense on mandatorily redeemable preferred shares	19,864	8,333
Non-cash interest expense on liability related to sale of future royalties	31,950	19,284
Non-cash expense related to license agreement	0	5,646
Change in fair value of derivatives	7,071	2,980
Loss from equity method investment	3,472	4,308
Depreciation and amortization	4,625	437
Other non-cash items	80	0
Changes in operating assets and liabilities:
Trade receivables, net	(79,522)	0
Inventories	(18,124)	0
Prepaid expenses and other current assets	(46,088)	1,494
Other assets	(45)	(352)
Accounts payable	27,898	810
Accrued expenses and other current liabilities	65,410	26,862
Other long-term liabilities	62	(2,000)
Net cash used in operating activities	(490,641)	(276,884)
Cash flows from investing activities:
Purchases of marketable securities	(230,233)	0
Purchases of property and equipment	(1,501)	(1,637)
Payments for leasehold improvements	(1,600)	0
Payments for intangible assets	(41,500)	0
Net cash used in investing activities	(274,834)	(1,637)
Cash flows from financing activities:
Proceeds from issuance of long-term debt	264,000	0
Proceeds from issuance of common shares	283,333	303,221
Proceeds from sale of future royalties	147,476	0
Proceeds from sale of contingently redeemable non-controlling interests	60,000	0
Proceeds from obligation to perform R&D services	2,124	0
Proceeds from issuance of mandatorily redeemable preferred shares	0	125,000
Proceeds from exercise of warrants	0	1,998
Payments of issuance costs	(2,300)	(1,150)
Payment of term loan commitment fee	(2,000)	0
Proceeds from exercise of stock options	17,815	2,777
Repayment of principal for finance leases	(991)	0
Net cash provided by financing activities	769,457	431,846
Effect of exchange rate changes on cash, cash equivalents and restricted cash	324	0
Net increase in cash, cash equivalents and restricted cash	4,306	153,325
Cash, cash equivalents and restricted cash at beginning of period	317,727	264,249
Cash, cash equivalents and restricted cash at end of period	322,033	417,574
Supplemental disclosure of cash flow information:
Cash paid for interest	2,564	0
Cash paid for income taxes	$ 1,406	$ 835