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Share-Based Compensation - Non-Cash Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Share-Based Compensation        
Non-cash share-based compensation expense $ 11,762 $ 17,554 $ 28,641 $ 24,884
Minimum        
Share-Based Compensation        
Requisite service period of award (in years)     3 years  
Maximum        
Share-Based Compensation        
Requisite service period of award (in years)     4 years  
Research and development expenses        
Share-Based Compensation        
Non-cash share-based compensation expense 6,426 10,330 $ 12,677 14,030
Selling, general and administrative expense        
Share-Based Compensation        
Non-cash share-based compensation expense $ 5,336 $ 7,224 $ 15,964 $ 10,854